CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028016
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CG7998 
Protein Synonyms/Alias
 IP09655p; RE60471p 
Gene Name
 Mdh2 
Gene Synonyms/Alias
 l(3)psg7; CG7998; Dmel_CG7998 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
164KAGVYDPKRLFGVSTacetylation[1]
225GNQDTIEKLTVRIQEacetylation[1]
239EAGTEVVKAKAGAGSacetylation[1]
264RFAGSLLKGLNGEKNacetylation[1]
313PKLNDYEKKLLEAAIacetylation[1]
329ELKKNIQKGIDFANAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 336 AA 
Protein Sequence
MLKQVTKQLA LQGVRTFSVG QQNNYKVTVC GAAGGIGQPL SLLLKQNPLV TDLALYDIVH 60
TPGVAADLSH IDTKSKTAGF IGADQLGDSL KGSDVVVIPA GVPRKPGMTR DDLFNVNAGI 120
IKDISNSIAK NCPKALVAII TNPVNTCVPI AAEILKKAGV YDPKRLFGVS TLDVVRARAF 180
IGHALGVDPQ TVQIPVIGGH SGVTILPVLS QSQPLFKGNQ DTIEKLTVRI QEAGTEVVKA 240
KAGAGSATLS MAYAGARFAG SLLKGLNGEK NVIECSYVQS TVTEATFFST PLVLGKNGVQ 300
ENLGLPKLND YEKKLLEAAI PELKKNIQKG IDFANA 336 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005739; C:mitochondrion; IDA:FlyBase.
 GO:0030060; F:L-malate dehydrogenase activity; IEA:EC.
 GO:0016615; F:malate dehydrogenase activity; IDA:FlyBase.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:FlyBase.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro.
 GO:0043068; P:positive regulation of programmed cell death; IMP:FlyBase.
 GO:0035209; P:pupal development; IMP:FlyBase.
 GO:0035070; P:salivary gland histolysis; IMP:FlyBase.
 GO:0006099; P:tricarboxylic acid cycle; IDA:FlyBase. 
Interpro
 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR010097; Malate_DH_type1.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 
SMART
  
PROSITE
  
PRINTS