| Tag | Content |
|---|
| CPLM ID | CPLM-016493 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 2A |
Protein Synonyms/Alias | eIF-2A |
Gene Name | Eif2a |
Gene Synonyms/Alias | D3Ertd194e |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 40 | RESGRNCKVYTFSKD | ubiquitination | [1] | | 169 | ANKLHLQKVNDFNLS | ubiquitination | [1] | | 192 | AVYVPGSKGAPSFVR | ubiquitination | [1] | | 427 | IFPAKTIKYQAVPSE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins (By similarity). |
Sequence Annotation | REPEAT 23 63 WD 1.
REPEAT 125 163 WD 2.
REPEAT 356 401 WD 3.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 503 503 Phosphoserine (By similarity).
MOD_RES 513 513 Phosphoserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Coiled coil; Complete proteome; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome; Repeat; Translation regulation; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 581 AA |
Protein Sequence | MAPSTPLLTV RGSEGLYMVN GPPHFTESTV LPRESGRNCK VYTFSKDGTL FAWSNGEKVN 60
IINVANKGLL HSFDLPKAVC LEFSPNNTVL ATWQPYTTSK DGTAGTPNLQ LYDMKTGACL 120
KSFIQKKMQN WCPSWSDDEI ICARNVNNEV HFFENNNFNT IANKLHLQKV NDFNLSPGTQ 180
PYKVAVYVPG SKGAPSFVRL YQYPNFAGPQ AALANKSFFK ADKVTMLWNK KATAVLVIAS 240
TEVDKTGASY YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT 300
VFNLKCDPVF DFGTGPRNAA FYSPHGHILV LAGFGNLRGQ MEVWDVKNYK LISKPVASDS 360
TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSLLHKY DVPSNGELWQ VSWQPFLDGI 420
FPAKTIKYQA VPSEVPSEEP KVATAYRPPA LRNKPVTNSK LHEEEPPQNM KPHPGSDKPL 480
SKTALKNQRK HEAKKAAKQE ARSDAAPTPV PQSAPRNTVT QSASGDPEVD KKIKNLKKKL 540
KAIEQLKEQA AAGKQLEKNQ LEKIQKETAL LQELEDLELG V 581 |
Gene Ontology | GO:0005850; C:eukaryotic translation initiation factor 2 complex; ISS:UniProtKB. GO:0043022; F:ribosome binding; ISS:UniProtKB. GO:0003743; F:translation initiation factor activity; ISS:UniProtKB. GO:0000049; F:tRNA binding; ISS:UniProtKB. GO:0009967; P:positive regulation of signal transduction; IDA:MGI. GO:0006468; P:protein phosphorylation; IDA:MGI. GO:0006417; P:regulation of translation; ISS:UniProtKB. GO:0042255; P:ribosome assembly; ISS:UniProtKB. GO:0032933; P:SREBP signaling pathway; IDA:MGI. |
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