CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034000
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alpha-2-macroglobulin 
Protein Synonyms/Alias
  
Gene Name
 Pzp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
324MKIEVEAKIKEEGTGubiquitination[1]
353LSKLKFTKVNTNYRPubiquitination[1]
866CICGNERKTVSWAVTubiquitination[1]
1015LTEAIKSKAINYLISubiquitination[1]
1088NWLSMKQKENGCFQQubiquitination[1]
1184ELLESLNKDAVKEEDubiquitination[1]
1205PGDVQKVKALSFYQPubiquitination[1]
1258KIVKWISKQQNSHGGubiquitination[1]
1281VALQALSKYGAATFTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1507 AA 
Protein Sequence
MRRNQLPTPA FLLLFLLLPR DATTATAKPQ YVVLVPSEVY SGVPEKACVS LNHVNETVML 60
SLTLEYAMQQ TKLLTDQAVD KDSFYCSPFT ISGSPLPYTF ITVEIKGPTQ RFIKKKSIQI 120
IKAESPVFVQ TDKPIYKPGQ IVKFRVVSVD ISFRPLNETF PVVYIETPKR NRIFQWQNIH 180
LAGGLHQLSF PLSVEPALGI YKVVVQKDSG KKIEHSFEVK EYVLPKFEVI IKMQKTMAFL 240
EEELPITACG VYTYGKPVPG LVTLRVCRKY SRYRSTCHNQ NSMSICEEFS QQADDKGCFR 300
QVVKTKVFQL RQKGHDMKIE VEAKIKEEGT GIELTGIGSC EIANALSKLK FTKVNTNYRP 360
GLPFSGQVLL VDEKGKPIPN KNITSVVSPL GYLSIFTTDE HGLANISIDT SNFTAPFLRV 420
VVTYKQNHVC YDNWWLDEFH TQADHSATLV FSPSQSYIQL ELVFGTLACG QTQEIRIHYL 480
LNEDIMKNEK DLTFYYLIKA RGSIFNLGSH VLSLEQGNMK GVFSLPIQVE PGMAPEAQLL 540
IYAILPNEEL VADAQNFEIE KCFANKVNLS FPSAQSLPAS DTHLKVKAAP LSLCALTAVD 600
QSVLLLKPEA KLSPQSIYNL LPGKTVQGAF FGVPVYKDHE NCISGEDITH NGIVYTPKHS 660
LGDNDAHSIF QSVGINIFTN SKIHKPRFCQ EFQHYPAMGG VAPQALAVAA SGPGSSFRAM 720
GVPMMGLDYS DEINQVVEVR ETVRKYFPET WIWDLVPLDV SGDGELAVKV PDTITEWKAS 780
AFCLSGTTGL GLSSTISLQA FQPFFLELTL PYSVVRGEAF TLKATVLNYM SHCIQIRVDL 840
EISPDFLAVP VGGHENSHCI CGNERKTVSW AVTPKSLGEV NFTATAEALQ SPELCGNKLT 900
EVPALVHKDT VVKSVIVEPE GIEKEQTYNT LLCPQDTELQ DNWSLELPPN VVEGSARATH 960
SVLGDILGSA MQNLQNLLQM PYGCGEQNMV LFVPNIYVLN YLNETQQLTE AIKSKAINYL 1020
ISGYQRQLNY QHSDGSYSTF GNHGGGNTPG NTWLTAFVLK AFAQAQSHIF IEKTHITNAF 1080
NWLSMKQKEN GCFQQSGYLL NNAMKGGVDD EVTLSAYITI ALLEMPLPVT HSAVRNALFC 1140
LETAWASISQ SQESHVYTKA LLAYAFALAG NKAKRSELLE SLNKDAVKEE DSLHWQRPGD 1200
VQKVKALSFY QPRAPSAEVE MTAYVLLAYL TSESSRPTRD LSSSDLSTAS KIVKWISKQQ 1260
NSHGGFSSTQ DTVVALQALS KYGAATFTRS QKEVLVTIES SGTFSKTFHV NSGNRLLLQE 1320
VRLPDLPGNY VTKGSGSGCV YLQTSLKYNI LPVADGKAPF ALQVNTLPLN FDKAGDHRTF 1380
QIRINVSYTG ERPSSNMVIV DVKMVSGFIP MKPSVKKLQD QPNIQRTEVN TNHVLIYIEK 1440
LTNQTLGFSF AVEQDIPVKN LKPAPIKVYD YYETDEFTVE EYSAPFSDGT VCSNLALNKE 1500
MLKSRNL 1507 
Gene Ontology
 GO:0005576; C:extracellular region; TAS:MGI.
 GO:0005615; C:extracellular space; IEA:InterPro.
 GO:0004866; F:endopeptidase inhibitor activity; IDA:MGI. 
Interpro
 IPR009048; A-macroglobulin_rcpt-bd.
 IPR011626; A2M_comp.
 IPR002890; A2M_N.
 IPR011625; A2M_N_2.
 IPR001599; Macroglobln_a2.
 IPR019742; MacrogloblnA2_CS.
 IPR019565; MacrogloblnA2_thiol-ester-bond.
 IPR008930; Terpenoid_cyclase/PrenylTrfase. 
Pfam
 PF00207; A2M
 PF07678; A2M_comp
 PF01835; A2M_N
 PF07703; A2M_N_2
 PF07677; A2M_recep
 PF10569; Thiol-ester_cl 
SMART
  
PROSITE
 PS00477; ALPHA_2_MACROGLOBULIN 
PRINTS