UniProt Accession

 E9PDQ8_HUMAN; E9PDQ8 

Genbank Protein ID

 AC099783; AC112213; AC113169; AC114401 

Genbank Nucleotide ID

  

Protein Name

 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 SUCLG2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
118	NVVGQLAKQMIGYNL	ubiquitination	[1]
227	QAADQITKLYNLFLK	acetylation	[2]
271	DNAEFRQKDIFAMDD	acetylation	[3]
291	PIENEAAKYDLKYIG	acetylation	[3]
338	LDLGGGVKEAQVYQA	acetylation	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003824; F:catalytic activity; IEA:InterPro. 

Interpro

 IPR013650; ATP-grasp_succ-CoA_synth-type.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR017866; Succ-CoA_synthase_bsu_CS.
 IPR005809; Succ_CoA_synthase_bsu.
 IPR016102; Succinyl-CoA_synth-like. 

Pfam

 PF08442; ATP-grasp_2 

SMART

  

PROSITE

 PS01217; SUCCINYL_COA_LIG_3 

PRINTS