| Tag | Content |
|---|
| CPLM ID | CPLM-000197 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Syntenin-1 |
Protein Synonyms/Alias | Scaffold protein Pbp1; Syndecan-binding protein 1 |
Gene Name | Sdcbp |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 186 | LKQAFGEKITMTIRD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. |
Sequence Annotation | DOMAIN 115 194 PDZ 1.
DOMAIN 199 273 PDZ 2.
MOD_RES 2 2 N-acetylserine (By similarity). |
Keyword | Acetylation; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 299 AA |
Protein Sequence | MSLYPSLEDL KVDKVIQAQT AYSANPASQA FVLVDASAAL PPDGNLYPKL YPELSQYMGL 60
SLNEAEICES MPMVSGAPAQ GQLVARPSSV NYMVAPVTGN DAGIRRAEIK QGIREVILCK 120
DQDGKIGLRL KSIDNGIFVQ LVQANSPASL VGLRFGDQVL QINGENCAGW SSDKAHKVLK 180
QAFGEKITMT IRDRPFERTV TMHKDSSGHV GFIFKSGKIT SIVKDSSAAR NGLLTDHHIC 240
EINGQNVIGL KDAQIADILS TAGTVVTITI MPTFIFEHII KRMAPSIMKS LMDHTIPEV 299 |
Gene Ontology | GO:0070062; C:extracellular vesicular exosome; IEA:Compara. GO:0005895; C:interleukin-5 receptor complex; IMP:UniProtKB. GO:0042470; C:melanosome; IEA:UniProtKB-SubCell. GO:0005137; F:interleukin-5 receptor binding; IMP:UniProtKB. GO:0042327; P:positive regulation of phosphorylation; IEA:Compara. GO:0007265; P:Ras protein signal transduction; IPI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |