CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023914
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal recognition particle receptor subunit beta 
Protein Synonyms/Alias
 SR-beta; Protein APMCF1 
Gene Name
 SRPRB 
Gene Synonyms/Alias
 PSEC0230 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
191IAMAKSAKLIQQQLEubiquitination[1, 2, 3, 4, 5]
199LIQQQLEKELNTLRVubiquitination[1, 4]
227TAPAQLGKKGKEFEFubiquitination[2, 5]
228APAQLGKKGKEFEFSubiquitination[4]
230AQLGKKGKEFEFSQLubiquitination[1, 2]
249EFLECSAKGGRGDVGubiquitination[2]
265ADIQDLEKWLAKIA*ubiquitination[1, 2, 4, 5]
269DLEKWLAKIA*****ubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity). 
Sequence Annotation
 NP_BIND 71 79 GTP (By similarity).
 NP_BIND 92 95 GTP (By similarity).
 BINDING 120 120 GTP; via amide nitrogen (By similarity).
 BINDING 248 248 GTP; via amide nitrogen (By similarity).  
Keyword
 Complete proteome; Endoplasmic reticulum; GTP-binding; Membrane; Nucleotide-binding; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 271 AA 
Protein Sequence
MASADSRRVA DGGGAGGTFQ PYLDTLRQEL QQTDPTLLSV VVAVLAVLLT LVFWKLIRSR 60
RSSQRAVLLV GLCDSGKTLL FVRLLTGLYR DTQTSITDSC AVYRVNNNRG NSLTLIDLPG 120
HESLRLQFLE RFKSSARAIV FVVDSAAFQR EVKDVAEFLY QVLIDSMGLK NTPSFLIACN 180
KQDIAMAKSA KLIQQQLEKE LNTLRVTRSA APSTLDSSST APAQLGKKGK EFEFSQLPLK 240
VEFLECSAKG GRGDVGSADI QDLEKWLAKI A 271 
Gene Ontology
 GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006412; P:translation; TAS:Reactome. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR024156; Small_GTPase_ARF.
 IPR019009; SRP_receptor_beta_su. 
Pfam
 PF09439; SRPRB 
SMART
  
PROSITE
  
PRINTS