CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036817
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 AF4/FMR2 family member 1 
Protein Synonyms/Alias
  
Gene Name
 AFF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
75LGNYEEVKEFLSTKSubiquitination[1]
318PSESPELKPLPEDYRubiquitination[1]
331YRQQTFEKTDLKVPAubiquitination[2]
335TFEKTDLKVPAKAKLubiquitination[2, 3]
341LKVPAKAKLTKLKMPubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 417 AA 
Protein Sequence
MAFTERVNSS GNSLYNDDRN LLRIREKERR NQEAHQEKEA FPEKIPLFGE PYKTAKGDEL 60
SSRIQNMLGN YEEVKEFLST KSHTHRLDAS ENRLGKPKYP LIPDKGSSIP SSSFHTSVHH 120
QSIHTPASGP LSVGNISHNP KMAQPRTEPM PSLHAKSCGP PDSQHLTQDR LGQEGFGSSH 180
HKKGDRRADG DHCASVTDSA PERELSPLIS LPSPVPPLSP IHSNQQTLPR TQGSSKVHGS 240
SNNSKGYCPA KSPKDLAVKV HDKETPQDSL VAPAQPPSQT FPPPSLPSKS VAMQQKPTAY 300
VRPMDGQDQA PSESPELKPL PEDYRQQTFE KTDLKVPAKA KLTKLKMPSQ SVEQTYSNEV 360
HCVEEILKDS QHVSSVTQNQ KQYDTSSKTH SNSQQGTSSM LEDDLQLSDS EDSDSEQ 417 
Gene Ontology
  
Interpro
 IPR007797; TF_AF4/FMR2. 
Pfam
 PF05110; AF-4 
SMART
  
PROSITE
  
PRINTS