| Tag | Content |
|---|
| CPLM ID | CPLM-030372 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hyperpolarization-activated, cyclic nucleotide-gated K+ 4 |
Protein Synonyms/Alias | MCG22630; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 |
Gene Name | Hcn4 |
Gene Synonyms/Alias | mCG_22630 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 238 | LRMFGSQKAVEREQE | ubiquitination | [1] | | 588 | IINFNCRKLVASMPL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | |
Keyword | Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1201 AA |
Protein Sequence | MDKLPPSMRK RLYSLPQQVG AKAWIMDEEE DGEEEGAGGR QDPSRRSIRL RPLPSPSPSV 60
AAGCSESRGA ALGATESEGP GRSAGKSSTN GDCRRFRGSL ASLGSRGGGS GGAGGGSSLG 120
HLHDSAEERR LIAAEGDASP GEDRTPPGLA TEPERPATAA QPAASPPPQQ PPQPASASCE 180
QPSADTAIKV EGGAAASDQI LPEAEVRLGQ SGFMQRQFGA MLQPGVNKFS LRMFGSQKAV 240
EREQERVKSA GFWIIHPYSD FRFYWDLTML LLMVGNLIII PVGITFFKDE NTTPWIVFNV 300
VSDTFFLIDL VLNFRTGIVV EDNTEIILDP QRIKMKYLKS WFVVDFISSI PVDYIFLIVE 360
TRIDSEVYKT ARALRIVRFT KILSLLRLLR LSRLIRYIHQ WEEIFHMTYD LASAVVRIVN 420
LIGMMLLLCH WDGCLQFLVP MLQDFPHDCW VSINGMVNNS WGKQYSYALF KAMSHMLCIG 480
YGRQAPVGMS DVWLTMLSMI VGATCYAMFI GHATALIQSL DSSRRQYQEK YKQVEQYMSF 540
HKLPPDTRQR IHDYYEHRYQ GKMFDEESIL GELSEPLREE IINFNCRKLV ASMPLFANAD 600
PNFVTSMLTK LRFEVFQPGD YIIREGTIGK KMYFIQHGVV SVLTKGNKET KLADGSYFGE 660
ICLLTRGRRT ASVRADTYCR LYSLSVDNFN EVLEEYPMMR RAFETVALDR LDRIGKKNSI 720
LLHKVQHDLN SGVFNYQENE IIQQIVRHDR EMAHCAHRVQ AAASATPTPT PVIWTPLIQA 780
PLQAAAATTS VAIALTHHPR LPAAIFRPPP GPGLGNLGAG QTPRHPRRLQ SLIPSALGSA 840
SPASSPSQVD TPSSSSFHIQ QLAGFSAPPG LSPLLPSSSS SPPPGACGSP PAPTPSTSTA 900
AAASTTGFGH FHKALGGSLS SSDSPLLTPL QPGARSPQAA QPPPPLPGAR GGLGLLEHFL 960
PPPPSSRSPS SSPGQLGQPP GELSLGLAAG PSSTPETPPR PERPSFMAGA SGGASPVAFT 1020
PRGGLSPPGH SPGPPRTFPS APPRASGSHG SLLLPPASSP PPPQVPQRRG TPPLTPGRLT 1080
QDLKLISASQ PALPQDGAQT LRRASPHSSG ESVAAFSLYP RAGGGSGSSG GLGPPGRPYG 1140
AIPGQHVTLP RKTSSGSLPP PLSLFGARAA SSGGPPLTTA APQREPGARS EPVRSKLPSN 1200
L 1201 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0043195; C:terminal bouton; IEA:Compara. GO:0005222; F:intracellular cAMP activated cation channel activity; IMP:MGI. GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. GO:0001701; P:in utero embryonic development; IMP:MGI. GO:0008016; P:regulation of heart contraction; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |