CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014141
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 B box and SPRY domain-containing protein 
Protein Synonyms/Alias
  
Gene Name
 BSPRY 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
69RAEELRNKIVDQCERubiquitination[1]
95VADVLPGKNQRAVSMubiquitination[1]
156HWAEALQKLDTIRTGubiquitination[1]
207EMLNFNEKCTRSPLLubiquitination[1]
258TLTFSTKKSKACADGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May regulate epithelial calcium transport by inhibiting TRPV5 activity (By similarity). 
Sequence Annotation
 DOMAIN 212 402 B30.2/SPRY.
 ZN_FING 17 65 B box-type.  
Keyword
 Alternative splicing; Calcium; Calcium transport; Complete proteome; Cytoplasm; Ion transport; Membrane; Metal-binding; Polymorphism; Reference proteome; Transport; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 402 AA 
Protein Sequence
MSAEGAEPGP GSGSGPGPGP LCPEHGQALS WFCGSERRPV CAACAGLGGR CRGHRIRRAE 60
ERAEELRNKI VDQCERLQLQ SAAITKYVAD VLPGKNQRAV SMASAARELV IQRLSLVRSL 120
CESEEQRLLE QVHGEEERAH QSILTQRVHW AEALQKLDTI RTGLVGMLTH LDDLQLIQKE 180
QEIFERTEEA EGILDPQESE MLNFNEKCTR SPLLTQLWAT AVLGSLSGTE DIRIDERTVS 240
PFLQLSDDRK TLTFSTKKSK ACADGPERFD HWPNALAATS FQNGLHAWMV NVQNSCAYKV 300
GVASGHLPRK GSGSDCRLGH NAFSWVFSRY DQEFRFSHNG QHEPLGLLRG PAQLGVVLDL 360
QVQELLFYEP ASGTVLCAHH VSFPGPLFPV FAVADQTISI VR 402 
Gene Ontology
 GO:0031252; C:cell leading edge; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR006574; PRY.
 IPR003877; SPRY_rcpt.
 IPR000315; Znf_B-box. 
Pfam
 PF00622; SPRY
 PF00643; zf-B_box 
SMART
 SM00589; PRY 
PROSITE
 PS50188; B302_SPRY
 PS50119; ZF_BBOX 
PRINTS
 PR01407; BUTYPHLNCDUF.