CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033528
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 4 
Protein Synonyms/Alias
  
Gene Name
 USP4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43LIDSRWFKQWKKYVGubiquitination[1]
120GQQPIVRKVVEHGLFubiquitination[1]
132GLFVKHCKVEVYLLEubiquitination[1]
158VLSCHFSKADTIATIubiquitination[1, 2]
167DTIATIEKEMRKLFNubiquitination[1]
186RETRLWNKYMSNTYEubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 363 AA 
Protein Sequence
MAEGGGCRER PDAETQKSEL GPLMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 120
VVEHGLFVKH CKVEVYLLEL KLCENSDPTN VLSCHFSKAD TIATIEKEMR KLFNIPAERE 180
TRLWNKYMSN TYEQLSKLDN TVQDAGLYQG QVLVIEPQNE DGTWPRQTLQ SKGPQEMLTQ 240
QGMALQNYDN KLVKCIEELC QKQEELCWQI QQEEDKKQRL QNEVRQLTEK LACVNEKLAR 300
VNENLARKIA SCSKFYQTIA ETEATYLKML ESSQTLLSVL KREAGNLTKA TASDQKSSGG 360
RDS 363 
Gene Ontology
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro. 
Interpro
 IPR006615; Pept_C19_DUSP. 
Pfam
 PF06337; DUSP 
SMART
 SM00695; DUSP 
PROSITE
 PS51283; DUSP 
PRINTS