CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019471
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tigger transposable element-derived protein 1 
Protein Synonyms/Alias
  
Gene Name
 TIGD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54VSQVVNAKEKFLKEVubiquitination[1]
56QVVNAKEKFLKEVKSubiquitination[1]
108SQSLIQNKALTLFNSubiquitination[1]
216VPGFKASKDRLTLLLubiquitination[1]
385FTILDAIKNIRDSWEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 6 57 HTH psq-type.
 DOMAIN 70 149 HTH CENPB-type.
 DOMAIN 178 403 DDE.
 DNA_BIND 33 53 H-T-H motif (By similarity).
 DNA_BIND 103 142 H-T-H motif (By similarity).  
Keyword
 Complete proteome; DNA-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 591 AA 
Protein Sequence
MASKCSSERK SRTSLTLNQK LEMIKLSEEG MSKAEIGRRL GLLRQTVSQV VNAKEKFLKE 60
VKSATPMNTR MIRKRNSLIA DMEKVLVVWI EDQTSRNIPL SQSLIQNKAL TLFNSMKAER 120
GVEAAEEKFE ASRGWFMRFK ERSHFHNIKA QGEAASADVE AAASYPEALA KIIDEGGYTK 180
QQIFNVDETA FYWKKMPSRT FIAREEKSVP GFKASKDRLT LLLGANAAGD FKLKPMLIYH 240
SENPRALKNY TKSTLPVLYK WNSKARMTAH LFTAWFTEYF KPTVETYCSE KKIPFKILLL 300
IDNAPSHPRA LMEIYEEINV IFMPANTTSI LQPMDQGVIS TFKSYYLRNT FHKALAAMDS 360
DVSDGSGQSK LKTFWKGFTI LDAIKNIRDS WEEVKLSTLT GVWKKLIPTL IDDYEGFKTS 420
VEEVSADVVE IAKELELEVE PEDVTELLQS HDKTLTDEEL FLMDAQRKWF LEMESTPGED 480
AVNIVEMTTK DLEYYINLVD KAAAGFERID SNFERSSTVG KMLSNSIACY REIFHERKSQ 540
LMRKASPMSY FRKLPQPPQP SAATTLTSQQ PSTSRQDPPP AKRVRLTEGS D 591 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR004875; DDE_SF_endonuclease_CENPB-like.
 IPR009057; Homeodomain-like.
 IPR006600; HTH_CenpB_DNA-bd_dom.
 IPR007889; HTH_Psq. 
Pfam
 PF04218; CENP-B_N
 PF03184; DDE_1
 PF03221; HTH_Tnp_Tc5 
SMART
 SM00674; CENPB 
PROSITE
 PS51253; HTH_CENPB
 PS50960; HTH_PSQ 
PRINTS