CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019452
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box/LRR-repeat protein 18 
Protein Synonyms/Alias
 F-box and leucine-rich repeat protein 18 
Gene Name
 FBXL18 
Gene Synonyms/Alias
 FBL18 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
76IHTVLLQKDYQASEDubiquitination[1]
138LTSLRLSKMLSALQHubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity). 
Sequence Annotation
 DOMAIN 25 72 F-box.
 REPEAT 77 103 LRR 1.
 REPEAT 104 128 LRR 2.
 REPEAT 129 153 LRR 3.
 REPEAT 177 201 LRR 4.
 REPEAT 324 352 LRR 5.
 REPEAT 367 392 LRR 6.
 REPEAT 393 422 LRR 7.
 REPEAT 468 492 LRR 8.
 REPEAT 516 540 LRR 9.
 REPEAT 542 567 LRR 10.
 REPEAT 572 597 LRR 11.
 REPEAT 599 623 LRR 12.  
Keyword
 Alternative splicing; Complete proteome; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 805 AA 
Protein Sequence
MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL NVRRTCRKLA 60
ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS MAGCYWLPGS TVEHVARCRS 120
LVKVNLSGCH LTSLRLSKML SALQHLRSLA IDVSPGFDAS QLSSECKATL SRVRELKQTL 180
FTPSYGVVPC CTSLEKLLLY FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG 240
YINQEVVRLY LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS 300
WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL SGCVHCLSPD 360
SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG LGRHLCQLLA RLRHLRSLSL 420
PVCSVADSAP RADRAPAQPA MHAVPRGFGK KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK 480
NLPFLEHLEL IGSNFSSAMP RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ 540
LPSVLTGSGL VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF 600
SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT GESLATCKSL 660
QQSLLRRWGE VTGRRPQLFT ELREEPSART SRATGRRQPC LPDSGVVCCP CGRPLAVSGI 720
ILVGVSPSLV VKTTCVYRVL FKNLDYASIF FLVCLFETES HSVVQAGVQW RDLSSLQPLL 780
SGLQPQPPEQ LENELEIGFS YCFVI 805 
Gene Ontology
  
Interpro
 IPR001810; F-box_dom_cyclin-like. 
Pfam
  
SMART
 SM00256; FBOX 
PROSITE
 PS50181; FBOX 
PRINTS