CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017391
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptopodin 
Protein Synonyms/Alias
  
Gene Name
 SYNPO 
Gene Synonyms/Alias
 KIAA1029 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
363GQAVPASKTGILEESubiquitination[1]
493RRQSRMEKYVIESSSubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity). 
Sequence Annotation
 MOTIF 562 565 PPxY motif.
 MOTIF 581 584 PPxY motif.
 MOD_RES 263 263 Phosphoserine.
 MOD_RES 501 501 Phosphoserine (By similarity).
 MOD_RES 525 525 Phosphoserine.
 MOD_RES 548 548 Phosphoserine (By similarity).
 MOD_RES 580 580 Phosphoserine.
 MOD_RES 685 685 Phosphoserine.
 MOD_RES 702 702 Phosphoserine.
 MOD_RES 746 746 Phosphothreonine.
 MOD_RES 754 754 Phosphoserine.
 MOD_RES 833 833 Phosphoserine.
 MOD_RES 882 882 Phosphoserine (By similarity).
 CARBOHYD 330 330 N-linked (GlcNAc...).  
Keyword
 Actin-binding; Alternative splicing; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse; Tight junction. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 929 AA 
Protein Sequence
MEGYSEEASL LRHLEKVASE EEEVPLVVYL KENAALLTAN GLHLSQNREA QQSSPAPPPA 60
EVHSPAADVN QNLASPSATL TTPTSNSSHN PPATDVNQNP PATVVPQSLP LSSIQQNSSE 120
AQLPSNGTGP ASKPSTLCAD GQPQAPAEEV RCSTLLIDKV STPATTTSTF SREATLIPSS 180
RPPASDFMSS SLLIDIQPNT LVVSADQEMS GRAAATTPTK VYSEVHFTLA KPPSVVNRTA 240
RPFGIQAPGG TSQMERSPML ERRHFGEKAP APQPPSLPDR SPRPQRHIMS RSPMVERRMM 300
GQRSPASERR PLGNFTAPPT YTETLSTAPL ASWVRSPPSY SVLYPSSDPK SSHLKGQAVP 360
ASKTGILEES MARRGSRKSM FTFVEKPKVT PNPDLLDLVQ TADEKRRQRD QGEVGVEEEP 420
FALGAEASNF QQEPAPRDRA SPAAAEEVVP EWASCLKSPR IQAKPKPKPN QNLSEASGKG 480
AELYARRQSR MEKYVIESSS HTPELARCPS PTMSLPSSWK YPTNAPGAFR VASRSPARTP 540
PASLYHGYLP ENGVLRPEPT KQPPYQLRPS LFVLSPIKEP AKVSPRAASP AKPSSLDLVP 600
NLPKGALPPS PALPRPSRSS PGLYTSPGQD SLQPTAVSPP YGGDISPVSP SRAWSPRAKQ 660
APRPSFSTRN AGIEAQDRRE SLPTSPPWTP GASRPPSSLD GWVSPGPWEP GRGSSMSSPP 720
PLPPPPPMSP SWSERSVSPL RPETEARPPS RQLQALLARN IINAARRKSA SPRSAGAENP 780
RPFSPPRAPP PPPPPPPPPP RMRSPQPARP GSAAVPGAAF APIPRSPLPA GPSSCTSPRS 840
PLPAPPRPFL YRRSPTDSDV SLDSEDSGAK SPGILGYNIC PRGWNGSLRL KRGSLPAEAS 900
CTT 903 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0043197; C:dendritic spine; TAS:UniProtKB.
 GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0032233; P:positive regulation of actin filament bundle assembly; IEA:Compara.
 GO:0051492; P:regulation of stress fiber assembly; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS