| Tag | Content |
|---|
| CPLM ID | CPLM-016925 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongation factor 4 |
Protein Synonyms/Alias | EF-4; Ribosomal back-translocase LepA |
Gene Name | lepA |
Gene Synonyms/Alias | LA_1888 |
Created Date | July 27, 2013 |
Organism | Leptospira interrogans serogroup Icterohaemorrhagiae serovar La |
NCBI Taxa ID | 189518 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 375 | ITTAPSVKYIIRSKN | methylation | [1] |
|
Reference | [1] High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans. Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH, Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R. Cell Res. 2010 Feb;20(2):197-210. [ PMID: 19918266] |
Functional Description | Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity). |
Sequence Annotation | NP_BIND 18 23 GTP (By similarity).
NP_BIND 135 138 GTP (By similarity). |
Keyword | Cell inner membrane; Cell membrane; Complete proteome; GTP-binding; Hydrolase; Membrane; Nucleotide-binding; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 600 AA |
Protein Sequence | MSDKQQFIRN FSIIAHIDHG KSTLADRLLE IGQVTNDRTK KDQILDSMDI ERERGITIKA 60
NNATFDYLAE DGNTYIMNLL DTPGHVDFTY EVSRSLKACE GVLLIVDASQ GVEAQTLANL 120
YLAMEQDLEI LPVMNKIDLP AADVEKTKIQ IEESLGLDPQ KAVAISAKTG LNVKEVLEQI 180
TKQIPSPKGN SNAPLKALVY DSYFDPYMGV VIKIRIFDGR IKKGDRILMM STGKDFTVNE 240
VGINRINLTP KESLETGEVG YIIAGIKKVS DAKTGDTVTL FSNPTKESVP GYKEAKPMVF 300
AGLFPINGEQ FDELVDAIEK LKLNDAALVF EKESSIALGF GFRVGYLGLL HMEIVQERLE 360
REFNLDLITT APSVKYIIRS KNGEVEEIDN PSRFPEPITI ESTEEPYVKA TVITPNEYVG 420
NIMSLAMDKR GIQLDTVYLT QDKVQLTYEI PLAELIFEFY DKLKSFTRGY ASLDYEPSGY 480
KASQLVKMDI LVNGEPVDAL SMIVHRSKAE QRGREIIEKL KDLIPRHQFM IPLQAAVGGK 540
ILARESISAL RKNVTAKCYG GDITRKKKLL EKQKEGKKRM KQIGNVEIPQ EAFLAVLKTS 600 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |