UniProt Accession

 VP37B_HUMAN; Q9H9H4 

Genbank Protein ID

 AK022812; BC005882 

Genbank Nucleotide ID

 BAB14255.1; AAH05882.1 

Protein Name

 Vacuolar protein sorting-associated protein 37B 

Protein Synonyms/Alias

 hVps37B; ESCRT-I complex subunit VPS37B 

Gene Name

 VPS37B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	TQNVQLNKEMTLASN	ubiquitination	[1, 2, 3]
70	QPQLDTLKARLTQKY	ubiquitination	[1, 2, 3]
145	FIDVYQSKRKLAHMR	ubiquitination	[1, 2, 3]
165	KLQEMVLKGQRLPQA	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. 

Sequence Annotation

 DOMAIN 84 173 VPS37 C-terminal.
 REGION 50 170 Interaction with IST1.  

Keyword

 Complete proteome; Endosome; Membrane; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0000813; C:ESCRT I complex; IDA:UniProtKB.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0046788; P:egress of virus within host cell; TAS:Reactome.
 GO:0016197; P:endosomal transport; TAS:Reactome.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0019082; P:viral protein processing; TAS:Reactome.
 GO:0019068; P:virion assembly; TAS:Reactome. 

Interpro

 IPR009851; Mod_r. 

Pfam

 PF07200; Mod_r 

SMART

  

PROSITE

 PS51314; VPS37_C 

PRINTS