| Tag | Content |
|---|
| CPLM ID | CPLM-016336 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase MARCH9 |
Protein Synonyms/Alias | Membrane-associated RING finger protein 9; Membrane-associated RING-CH protein IX; MARCH-IX; RING finger protein 179 |
Gene Name | MARCH9 |
Gene Synonyms/Alias | RNF179 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 281 | AGGGTAGKSGPRNSR | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
Sequence Annotation | ZN_FING 102 162 RING-CH-type. |
Keyword | Alternative splicing; Complete proteome; Golgi apparatus; Ligase; Lysosome; Membrane; Metal-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 346 AA |
Protein Sequence | MLKSRLRMFL NELKLLVLTG GGRPRAEPQP RGGRGGGCGW APFAGCSTRD GDGDEEEYYG 60
SEPRARGLAG DKEPRAGPLP PPAPPLPPPG ALDALSLSSS LDSGLRTPQC RICFQGPEQG 120
ELLSPCRCDG SVRCTHQPCL IRWISERGSW SCELCYFKYQ VLAISTKNPL QWQAISLTVI 180
EKVQIAAIVL GSLFLVASIS WLIWSSLSPS AKWQRQDLLF QICYGMYGFM DVVCIGLIIH 240
EGSSVYRIFK RWQAVNQQWK VLNYDKTKDI GGDAGGGTAG KSGPRNSRTG PTSGATSRPP 300
AAQRMRTLLP QRCGYTILHL LGQLRPPDAR SSSHSGREVV MRVTTV 346 |
Gene Ontology | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005795; C:Golgi stack; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. GO:0005802; C:trans-Golgi network; IDA:UniProtKB. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |