CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041026
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nitric oxide synthase, brain 
Protein Synonyms/Alias
  
Gene Name
 Nos1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
24SVRLFKRKVGGLGFLubiquitination[1]
131QPLGTPTKAVDLSRQubiquitination[1]
216SILTGGGKAVNRGGPubiquitination[1]
739KKLAEAVKFSAKLMGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1463 AA 
Protein Sequence
MEEHTFGVQQ IQPNVISVRL FKRKVGGLGF LVKERVSKPP VIISDLIRGG AAEQSGLIQA 60
GDIILAVNDR PLVDLSYDSA LEVLRGIASE THVVLILRGP EGFTTHLETT FTGDGTPKTI 120
RVTQPLGTPT KAVDLSRQPS ASKDQPLAVD RVPGPSNGPQ HAQGRGQGAG SVSQANGVAI 180
DPTMKNTKAN LQDSGEQDEL LKEIEPVLSI LTGGGKAVNR GGPAKAEMKD TGIQVDRDLD 240
GKLHKAPPLG GENDRVFNDL WGKGNVPVVL NNPYSENEQS PASGKQSPTK NGSPSRCPRF 300
LKVKNWETDV VLTDTLHLKS TLETGCTEQI CMGSIMLPSH HIRKSEDVRT KDQLFPLAKE 360
FLDQYYSSIK RFGSKAHMDR LEEVNKEIES TSTYQLKDTE LIYGAKHAWR NASRCVGRIQ 420
WSKLQVFDAR DCTTAHGMFN YICNHVKYAT NKGNLRSAIT IFPQRTDGKH DFRVWNSQLI 480
RYAGYKQPDG STLGDPANVE FTEICIQQGW KPPRGRFDVL PLLLQANGND PELFQIPPEL 540
VLEVPIRHPK FDWFKDLGLK WYGLPAVSNM LLEIGGLEFS ACPFSGWYMG TEIGVRDYCD 600
NSRYNILEEV AKKMDLDMRK TSSLWKDQAL VEINIAVLYS FQSDKVTIVD HHSATESFIK 660
HMENEYRCRG GCPADWVWIV PPMSGSITPV FHQEMLNYRL TPSFEYQPDP WNTHVWKGTN 720
GTPTKRRAIG FKKLAEAVKF SAKLMGQAMA KRVKATILYA TETGKSQAYA KTLCEIFKHA 780
FDAKAMSMEE YDIVHLEHEA LVLVVTSTFG NGDPPENGEK FGCALMEMRH PNSVQEERKY 840
PEPLRFFPRK GPSLSHADSE AHSLVAARDS QHRSYKVRFN SVSSYSDSRK SSGDGPDLRD 900
NFESTGPLAN VRFSVFGLGS RAYPHFCAFG HAVDTLLEEL GGERILKMRE GDELCGQEEA 960
FRTWAKKVFK AACDVFCVGD DVNIEKANNS LISNDRSWKR NKFRLTYVAE APELTQGLSN 1020
VHKKRVSAAR LLSRQNLQSP KSSRSTIFVR LHTNGNQELQ YQPGDHLGVF PGNHEDLVNA 1080
LIERLEDAPP ANHVVKVEML EERNTALGVI SNWKDESRLP PCTIFQAFKY YLDITTPPTP 1140
LQLQQFASLA TNEKEKQRLL VLSKGLQEYE EWKWGKNPTM VEVLEEFPSI QMPATLLLTQ 1200
LSLLQPRYYS ISSSPDMYPD EVHLTVAIVS YHTRDGEGPV HHGVCSSWLN RIQADDVVPC 1260
FVRGAPSFHL PRNPQVPCIL VGPGTGIAPF RSFWQQRQFD IQHKGMNPCP MVLVFGCRQS 1320
KIDHIYREET LQAKNKGVFR ELYTAYSREP DRPKKYVQDV LQEQLAESVY RALKEQGGHI 1380
YVCGDVTMAA DVLKAIQRIM TQQGKLSEED AGVFISRLRD DNRYHEDIFG VTLRTYEVTN 1440
RLRSESIAFI EESKKDTDEV FSS 1463 
Gene Ontology
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005739; C:mitochondrion; ISO:MGI.
 GO:0045202; C:synapse; IDA:MGI.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0003958; F:NADPH-hemoprotein reductase activity; IBA:RefGenome.
 GO:0004517; F:nitric-oxide synthase activity; IEA:InterPro.
 GO:0042738; P:exogenous drug catabolic process; IMP:MGI.
 GO:0045776; P:negative regulation of blood pressure; IBA:RefGenome.
 GO:0051926; P:negative regulation of calcium ion transport; IMP:MGI.
 GO:0051346; P:negative regulation of hydrolase activity; IMP:MGI.
 GO:0043267; P:negative regulation of potassium ion transport; IMP:MGI.
 GO:0006809; P:nitric oxide biosynthetic process; IEA:InterPro.
 GO:0007263; P:nitric oxide mediated signal transduction; IBA:RefGenome.
 GO:0018119; P:peptidyl-cysteine S-nitrosylation; IDA:MGI.
 GO:0031284; P:positive regulation of guanylate cyclase activity; IBA:RefGenome.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0045909; P:positive regulation of vasodilation; IBA:RefGenome.
 GO:0002028; P:regulation of sodium ion transport; IMP:MGI.
 GO:0006941; P:striated muscle contraction; IMP:MGI. 
Interpro
 IPR003097; FAD-binding_1.
 IPR017927; Fd_Rdtase_FAD-bd.
 IPR001094; Flavdoxin.
 IPR008254; Flavodoxin/NO_synth.
 IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
 IPR023173; NADPH_Cyt_P450_Rdtase_dom3.
 IPR004030; NO_synthase_oxygenase_dom.
 IPR026009; NOS.
 IPR012144; NOS_met.
 IPR001433; OxRdtase_FAD/NAD-bd.
 IPR001478; PDZ.
 IPR017938; Riboflavin_synthase-like_b-brl. 
Pfam
 PF00667; FAD_binding_1
 PF00258; Flavodoxin_1
 PF00175; NAD_binding_1
 PF02898; NO_synthase
 PF00595; PDZ 
SMART
 SM00228; PDZ 
PROSITE
 PS51384; FAD_FR
 PS50902; FLAVODOXIN_LIKE
 PS60001; NOS
 PS50106; PDZ 
PRINTS
 PR00369; FLAVODOXIN.
 PR00371; FPNCR.