CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032980
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mismatch repair endonuclease PMS2 
Protein Synonyms/Alias
  
Gene Name
 PMS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
40HNGKIIQKTPYPRPRubiquitination[1, 2, 3]
104TNQLGQGKRQPVVCTacetylation[3]
195RRPCDPAKVCRLVNEubiquitination[2]
642ENLEIFRKNGFDFVIubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 756 AA 
Protein Sequence
MWGRRRKLRR LNDVTISTCH ASAKVGTRLM FDHNGKIIQK TPYPRPRGTT VSVQQLFSTL 60
PVRHKEFQRN IKKEYAKMVQ VLHAYCIISA GIRVSCTNQL GQGKRQPVVC TGGSPSIKEN 120
IGSVFGQKQL QSLIPFVQLP PSDSVCEEYG LSCSDALHNL FYISGFISQC THGVGRSSTD 180
RQFFFINRRP CDPAKVCRLV NEVYHMYNRH QYPFVVLNIS VDSECVDINV TPDKRQILLQ 240
EEKLLLAVLK TSLIGMFDSD VNKLNVSQQP LLDVEGNLIK MHAADLEKPM VEKQDQSPSL 300
RTGEEKKDVS ISRLREAFSL RHTTENKPHS PKTPEPRRSP LGQKRGMLSS STSGAISDKG 360
VLRPQKEAVS SSHGPSDPTD RAEVEKDSGH GSTSVDSEGF SIPDTGSHCS SEYAASSPGD 420
RGSQEHVDSQ EKAPKTDDSF SDVDCHSNQE DTGCKFRVLP QPTNLATPNT KRFKKEEILS 480
SSDICQKLVN TQDMSASQVD VAVKINKKVV PLDFSMSSLA KRIKQLHHEA QQSEGEQNYR 540
KFRAKICPGE NQAAEDELRK EISKTMFAEM EIIGQFNLGF IITKLNEDIF IVDQHATDEK 600
YNFEMLQQHT VLQGQRLIAP QTLNLTAVNE AVLIENLEIF RKNGFDFVID ENAPVTERAK 660
LISLPTSKNW TFGPQDVDEL IFMLSDSPGV MCRPSRVKQM FASRACRKSV MIGTALNTSE 720
MKKLITHMGE MDHPWNCPHG RPTMRHIANL GVISQN 756 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0030983; F:mismatched DNA binding; IEA:InterPro.
 GO:0006298; P:mismatch repair; IEA:InterPro. 
Interpro
 IPR002099; DNA_mismatch_repair.
 IPR013507; DNA_mismatch_repair_C.
 IPR003594; HATPase_ATP-bd.
 IPR014790; MutL_C.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF01119; DNA_mis_repair
 PF08676; MutL_C 
SMART
 SM00853; MutL_C 
PROSITE
  
PRINTS