| Tag | Content |
|---|
| CPLM ID | CPLM-005645 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Proteasome subunit beta type-8 |
Protein Synonyms/Alias | Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i |
Gene Name | Psmb8 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 252 | VVNMYHMKKDGWVKV | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Required for adipocyte differentiation (By similarity). |
Sequence Annotation | ACT_SITE 73 73 Nucleophile (By similarity). |
Keyword | Complete proteome; Cytoplasm; Differentiation; Hydrolase; Immunity; Nucleus; Protease; Proteasome; Reference proteome; Threonine protease; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 276 AA |
Protein Sequence | MALLDLCGAP RGQRPEWAAV DAGSGLRSDP GHYSFSVQAP ELALPRGMQP TEFLRSFGDD 60
QERKVQIEMA HGTTTLAFKF QHGVIVAVDS RASAGSYIAT IRVNKVIEIN PYLLGTMSGC 120
AADCQYWERL LAKECRLYYL RNGERISVSA ASKLLSNMML QYRGMGLSMG SMICGWDKKG 180
PGLYYVDDNG TRLSGQMFST GSGNTYAYGV MDSGYRQDLS PEEAYDLARR AIVYATHRDS 240
YSGGVVNMYH MKKDGWVKVE STDVSDLLHK YREATL 276 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005839; C:proteasome core complex; ISS:UniProtKB. GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW. GO:0019882; P:antigen processing and presentation; NAS:RGD. GO:0045444; P:fat cell differentiation; ISS:UniProtKB. GO:0051603; P:proteolysis involved in cellular protein catabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |