| Tag | Content |
|---|
| CPLM ID | CPLM-011225 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transducin-like enhancer protein 1 |
Protein Synonyms/Alias | E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG1 |
Gene Name | TLE1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 281 | DKNRLLKKDASSSPA | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
Sequence Annotation | REPEAT 470 501 WD 1.
REPEAT 528 558 WD 2.
REPEAT 572 602 WD 3.
REPEAT 614 644 WD 4.
REPEAT 696 726 WD 5.
REPEAT 737 767 WD 6.
REGION 200 268 CCN domain.
MOTIF 225 228 Nuclear localization signal (Potential).
MOD_RES 239 239 Phosphoserine.
MOD_RES 259 259 Phosphoserine; by CDK1 (Potential).
MOD_RES 263 263 Phosphoserine; by CDK1 (Potential).
MOD_RES 267 267 Phosphoserine; by CDK1 (Potential).
MOD_RES 284 284 Phosphoserine (By similarity).
MOD_RES 286 286 Phosphoserine. |
Keyword | 3D-structure; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 770 AA |
Protein Sequence | MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 60
YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 120
AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SAGLLALSSA LSGQSHLAIK 180
DDKKHHDAEH HRDREPGTSN SLLVPDSLRG TDKRRNGPEF SNDIKKRKVD DKDSSHYDSD 240
GDKSDDNLVV DVSNEDPSSP RASPAHSPRE NGIDKNRLLK KDASSSPAST ASSASSTSLK 300
SKEMSLHEKA STPVLKSSTP TPRSDMPTPG TSATPGLRPG LGKPPAIDPL VNQAAAGLRT 360
PLAVPGPYPA PFGMVPHAGM NGELTSPGAA YASLHNMSPQ MSAAAAAAAV VAYGRSPMVG 420
FDPPPHMRVP TIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT 480
LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP 540
DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV 600
WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI 660
FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN 720
LLNAWRTPYG ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY 770 |
Gene Ontology | GO:0005829; C:cytosol; IMP:UniProtKB. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0005667; C:transcription factor complex; IEA:Compara. GO:0003682; F:chromatin binding; IEA:Compara. GO:0001106; F:RNA polymerase II transcription corepressor activity; IDA:BHF-UCL. GO:0008134; F:transcription factor binding; IDA:UniProtKB. GO:2000811; P:negative regulation of anoikis; IMP:UniProtKB. GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB. GO:0030178; P:negative regulation of Wnt receptor signaling pathway; NAS:UniProtKB. GO:0007219; P:Notch signaling pathway; TAS:Reactome. GO:0009887; P:organ morphogenesis; TAS:ProtInc. GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
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