| Tag | Content |
|---|
| CPLM ID | CPLM-028027 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Malic enzyme |
Protein Synonyms/Alias | |
Gene Name | Men |
Gene Synonyms/Alias | CG10120; Dmel_CG10120 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 195 | KPDSKLDKYAQRDRL | acetylation | [1] | | 531 | GLTEEEAKARIWMVD | acetylation | [1] | | 695 | RLAELVSKDDLAKGS | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | |
Sequence Annotation | ACT_SITE 305 305 Proton donor (By similarity).
ACT_SITE 376 376 Proton acceptor (By similarity).
METAL 448 448 Divalent metal cation (By similarity).
METAL 449 449 Divalent metal cation (By similarity).
METAL 472 472 Divalent metal cation (By similarity). |
Keyword | Complete proteome; Metal-binding; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 763 AA |
Protein Sequence | MGNSSSICAD RNVITNFDEN GTPVYPTANN SQSPSSYSRG KERELGCYTK RNSNSNNNNS 60
HERESQSCCS SRVCKNHTTT TTTTLEYELS NFAKLTTRIT TQSAAEVDTS PHTDTETHRD 120
RDSNPGNIAL ATDLELPKGL PLSLSSRHHW NQLQSSLHAL HHQQQQQQQQ LRSYSSTSET 180
NLEDKMSKPD SKLDKYAQRD RLGLWGTGDN EVVGSLSGFT RLLDKRYSKG LAFTHEERQQ 240
LGIHGMLPYV VREPSEQVEH CRALLARLDQ DLDKYMYLIS LSERNERLFY NVLSSDIAYM 300
MPLVYTPTVG LACQRYSLIH QNAKGMFISI KDKGHIYDVL KNWPETDVRA IVVTDGERIL 360
GLGDLGANGM GIPVGKLSLY TALAGIKPSQ CLPITLDVGT NTESILEDPL YIGLRERRAT 420
GDLYDEFIDE FMHACVRRFG QNCLIQFEDF ANANAFRLLS KYRDSFCTFN DDIQGTASVA 480
VAGLLASLKI KKTQLKDNTL LFLGAGEAAL GIANLCLMAM KVEGLTEEEA KARIWMVDSR 540
GVITRDRPKG GLTEHKLHFA QLHEPIDTLA EAVRKVRPNV LIGAAAQGGA FNQEILELMA 600
DINETPIIFA LSNPTSKAEC TAEEAYTYTK GRCIFASGSP FAPVTYNNKK FYPGQGNNSY 660
IFPGVALGVL CAGMLNIPEQ VFLVAAERLA ELVSKDDLAK GSLYPPLSSI VSCSMAIAER 720
IVEYAYKNGL ATVRPEPVNK LAFIKAQMYD LDYPRSVPAT YKM 763 |
Gene Ontology | GO:0016619; F:malate dehydrogenase (oxaloacetate-decarboxylating) activity; IEA:InterPro. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0051287; F:NAD binding; IEA:InterPro. GO:0008340; P:determination of adult lifespan; IMP:FlyBase. GO:0006108; P:malate metabolic process; IEA:InterPro. GO:0010941; P:regulation of cell death; IMP:FlyBase. GO:0030431; P:sleep; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |