CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024016
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Insulin-like growth factor 2 mRNA-binding protein 2 
Protein Synonyms/Alias
 IGF2 mRNA-binding protein 2; IMP-2; Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; VICKZ family member 2 
Gene Name
 IGF2BP2 
Gene Synonyms/Alias
 IMP2; VICKZ2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
77EVDYSVSKKLRSRKIubiquitination[1]
221LTIKNITKQTQSRVDubiquitination[1]
270QKEADETKLAEEIPLubiquitination[1]
278LAEEIPLKILAHNGLubiquitination[1, 2, 3]
462RFAGASIKIAPAEGPubiquitination[1, 2, 3]
487GPPEAQFKAQGRIFGubiquitination[1]
497GRIFGKLKEENFFNPubiquitination[1]
588QVKQQEQKYPQGVASubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. 
Sequence Annotation
 DOMAIN 3 76 RRM 1.
 DOMAIN 82 157 RRM 2.
 DOMAIN 193 258 KH 1.
 DOMAIN 274 341 KH 2.
 DOMAIN 427 492 KH 3.
 DOMAIN 509 575 KH 4.
 MOD_RES 162 162 Phosphoserine.
 MOD_RES 164 164 Phosphoserine.  
Keyword
 3D-structure; Alternative initiation; Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 599 AA 
Protein Sequence
MMNKLYIGNL SPAVTADDLR QLFGDRKLPL AGQVLLKSGY AFVDYPDQNW AIRAIETLSG 60
KVELHGKIME VDYSVSKKLR SRKIQIRNIP PHLQWEVLDG LLAQYGTVEN VEQVNTDTET 120
AVVNVTYATR EEAKIAMEKL SGHQFENYSF KISYIPDEEV SSPSPPQRAQ RGDHSSREQG 180
HAPGGTSQAR QIDFPLRILV PTQFVGAIIG KEGLTIKNIT KQTQSRVDIH RKENSGAAEK 240
PVTIHATPEG TSEACRMILE IMQKEADETK LAEEIPLKIL AHNGLVGRLI GKEGRNLKKI 300
EHETGTKITI SSLQDLSIYN PERTITVKGT VEACASAEIE IMKKLREAFE NDMLAVNQQA 360
NLIPGLNLSA LGIFSTGLSV LSPPAGPRGA PPAAPYHPFT THSGYFSSLY PHHQFGPFPH 420
HHSYPEQEIV NLFIPTQAVG AIIGKKGAHI KQLARFAGAS IKIAPAEGPD VSERMVIITG 480
PPEAQFKAQG RIFGKLKEEN FFNPKEEVKL EAHIRVPSST AGRVIGKGGK TVNELQNLTS 540
AEVIVPRDQT PDENEEVIVR IIGHFFASQT AQRKIREIVQ QVKQQEQKYP QGVASQRSK 599 
Gene Ontology
 GO:0005856; C:cytoskeleton; IDA:BHF-UCL.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003730; F:mRNA 3'-UTR binding; IDA:UniProtKB.
 GO:0048027; F:mRNA 5'-UTR binding; IDA:BHF-UCL.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0045182; F:translation regulator activity; ISS:BHF-UCL.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0017148; P:negative regulation of translation; ISS:BHF-UCL.
 GO:0042035; P:regulation of cytokine biosynthetic process; IC:BHF-UCL. 
Interpro
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00013; KH_1
 PF00076; RRM_1 
SMART
 SM00322; KH
 SM00360; RRM 
PROSITE
 PS50084; KH_TYPE_1
 PS50102; RRM 
PRINTS