CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028740
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Midasin 
Protein Synonyms/Alias
  
Gene Name
 Mdn1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
2115PWRLLLEKVERTVRVacetylation[1]
2115PWRLLLEKVERTVRVsuccinylation[1]
4819GNLNKNKKHQDEKEDacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
 Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Nucleotide-binding; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5589 AA 
Protein Sequence
MEHLSVELVS GPLRLIAAKN EKSSGELNRF LAKSVWTPQD RQCILDSLAQ LLLDKDYTLL 60
LGRQLRPILL DLLERNAKAI KTGGQVNHDL HERLSVSMSK LIGSHPDVLP FALRYFKDTY 120
PVFQRLFLES SDANPVRYGR RRMKLRDLME AANIFLQHRQ TVFRELWDWS VCVPLLRSHD 180
ALVRWHTANC LALVTCMNEE HKLSFLRKIF SSDELVHFRL RLLEEAQLQD LEKALVLANP 240
EVSLWHKGEE PQYIQGHLVS ADLSSSVAAV CGVVLPKLSS SPGEQASDRS SSLEQELALK 300
SFVLVESVCK NLQLLAVSVA SQNAVLLEGP IGSGKTSLVE HLAAVTGRTK PPQLLKVQLG 360
DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATKGYWILL EDIDYAPLDV VSVLIPLLEH 420
GELLIPGHGD CLKVAPTFQL FATRRLLSCG GSWYRPMNSH ATMLDKYWTK IHLHNLNKKD 480
LNEVLQSKYP SLLAATDHLL DIYIELTGEK HCCPSVAYDK APQEVSEAER ENRRVVLEGR 540
ELSLRDLLNW CNRVAHGFDP TSSTALLHIF QEAMDCFTAM LSEQTKKLRM AEVIGSRLNI 600
SKKKAEFYCK LYKPEIVINE LDVQVGRVRL LRKQSEVVRI QKEKCTFAAT RPSSVLLEQL 660
AVCVSQGEPV LLVGETGTGK TSAVQYLAYA TGQHLRVVNM NQQSDTADLL GGFKPVDHKL 720
IWLPLRETFE ELFVQTFSKK QNFTFLGHIQ TCYRQKRWHD LLKLMLHVQK SASTKGGEQS 780
QPGLLKEKWE AFGLRLNHAQ QQMKMTENAL LFAFVEGTLA QAIKKGEWIL LDEINLAAPE 840
TLECLSGLLE GSSGSLVLLD RGDTEPLVRH PDFRLFACMN PATDVGKRNL PPGIRNRFTE 900
LYVEELESKE DLQILIVDYL KGLNVSKNTV QGIVNFYTAL RKESGTKLVD GTGHRPHYSL 960
RTLCRALRFA ASNPCGSIQR SLYEGFCLGF LTQLDRASHP VVQKLICQHI ISGNVKSLLK 1020
QPIPEPKGGR LIQVEGYWIS VGDKEPKIDE TYVLTPSVKL NLRDIARVVS AGTYPVLIQG 1080
ETSVGKTSLI RWLAAASGNH CVRINNHEHT DIQEYIGCYT SDTSGKLVFN EGVLIDAMRK 1140
GYWIVLDELN LAPTDVLEAL NRLLDDNREL LITETQEVVR AHPRFMLFAT QNPPGLYGGR 1200
KVLSRAFRNR FVELHFDELP SSELETILHK RCSLPPSYCS KLVKVMLDLQ SYRRRSSVFA 1260
GKQGFIALRD LFRWAERYRL AEQTQEDYDW LQHLANDGFM LLAGRVRKQE EADVIQEVLE 1320
KHFKKKLCPQ SLFSKENVLK LLGKSSTQTT VLESKFSHVV WTESMRRLAV LVGRALEFGE 1380
PVLLVGDTGC GKTTVCQMFS ALANQKLYSV NCHLNMETSD FLGGLRPVRQ KPNDKDELDT 1440
RLFEWHDGPL VLAMKEDSFF LLDEISLADD SVLERLNSVL EVEKCLVLAE KGSPESKDNE 1500
VELLTAGKHF RILATMNPGG DFGKKELSPA LRNRFTEIWC PQSTKREDLI QIINHNLRPG 1560
LSLAGVGHKG AGVAEVMLAF ITWLTRQEFG RKCVVSIRDI LSWVNFMNSM AEDAAVKRPE 1620
AISTVTSFVH AACLVYIDGI GSGVTSSGFG TALLAREECL KFLIKKLSKV VRLTQRQKDE 1680
LKIYDRLRHK EFTSIDDFWG VHPFFIPRGP VLDGHNTGDY ALTAGTTAMN AQRLLRAAKL 1740
NKPILLEGSP GVGKTSLVAA LAKASGNTLV RINLSEQTDI TDLFGADLPV EGGRGGEFAW 1800
CDGPLLAALK AGHWVVLDEL NLASQSILEG LNACFDHRGE IYVPELGMSF QVQHEKTRIF 1860
GCQNPFRQGG GRKGLPKSFL NRFTQVFVDP LTVVDMEFIA STLFPTIDKD IVKKMVAFNN 1920
HIDHEVTVEK KWGQKGGPWE FNLRDLFRWC QLILVDQSPG CYDPGQHVFL VYGERMRTRE 1980
DKEKVVAVFK DVFASNSMPY IGTRQFHITP YDIQIGYSVL SRSSYVPHPS RRPLSLLHQS 2040
FQSLEPIMKC VQMNWMVILV GPASVGKTSL VQLLAHLTGH TLKIMAMNSA MDTTELLGGF 2100
EQVDIIRPWR LLLEKVERTV RVLLRDSLLI NSVDTEVVLQ AWSHFLLTYK PKCLGEDGKG 2160
VTIEIVNKLE AVLLLMQRLN NKINSYSKAD FAKLVEDFRS FGVKLLQSAS GRSHGSFEWV 2220
DSMLVQALKS GDWLLMDNVN FCNPSVLDRL NALLEPGGVL TINERGMVDG STCTVTPNPN 2280
FRLFLSMDPI HGEISRAMRN RGLEIYISGE EDGSIQDNLD LKVLLHSLGL VGDSVCNILL 2340
ALHTEIQSLV RGSPASSVST LSHTAILIVQ YLQRGLSLHK AFFEACWEVY VCSQHSAANQ 2400
KLVQDLLESH TASLQARETW GHSILATGLW PDSVPSALFA TEDSRLSVVR SEGQILAYCL 2460
NRMSLKTSSW TRSQPLTLQD LENIMQTCSP DDLTFNAVEV DTCWVDEPEV LATAVKLLIE 2520
RATNQDWMLR VKWLCHLAKN IPQGLESVRV HLEASATALR KFYSTSLSAG VSNVLKILQT 2580
NITDDFVIPL DPRWNMQALD IIRNSLDFDP QSDQAKQLFA LLESVANKTF IYLDREKRIF 2640
TEANLVSVGS KKLRSSVLRM SFEFHKDPEN YHSPPHEIVA NLAAFFELID GLILLWVQSP 2700
QGVVPDAHIN KILGSVQWRD RFWTVADTVT VDASGLALLA LHWHWVSKHL IYQIPQLLVN 2760
QENKYYKELQ TVSEHIHSCL GSPADSFAGV KKLQAFLGRP FPFKDKLVVD CFLQLQALNR 2820
ALAIGEQLPV FGECGWQEDI NRLQVVASEW NLKKSLLQAW GLILRANILE DVNLDELKNL 2880
VSTQCSELKS RGLSRGFLEK AHDASSPSQP DLSSLVHLTR RVQLWPAAEY LAMLWQYRVT 2940
ADFIAQACLR RSSKHDQMDE EISHHIAFCL KHTPIAPQKL WNLWSLLHIE MLSAQEVSCL 3000
WSELFTSTFG SSWSSPVTTA PECWLAWSPL PNIQQQEVPR SRWDSTLKGP GSLCRAVFSK 3060
CCFGVLTNSS RASYWDVSGL PLLSSSHVTL GEWVERAQQL QDISSLLWTN MAVPSVAEFR 3120
RTDSRLQGLV LCRYLLGLTE LLPAHQRQEY MQNCEHLLLG NTQAFHHVDQ TMGNIGGQEA 3180
LPKELLCLLL TSLHYFIGEG EGKQNLPEAA RRGRLWVSLG LLQIQTWLPR ARFDPAVKKA 3240
YKLRYAQDEL RQLQCELKTR NLLSHLQTGR DLEDDIITSH SHPHIKLLPQ RISQLESLVH 3300
SLSKKQAFRP HLPSYETLVQ EIHHYVTSIA KVTAVQDLLM RLLQALHTDG PKSAQVLQNL 3360
LKEEASWQQS HHQFRKRLVE EYALYPDTVA PLLASILQLQ HGMRLVASEV HASLHSGVLC 3420
AENLGALAMA VLAFPSVGPS FPTYHAHADA LCSVNAAEAL RSLGKLMVKR AARKEEAKSQ 3480
QAYPTREQLL MNALLYLRSH VLCKGELDQR ALLLFRHLCQ EIINEWDEQE RIAQEKAEQE 3540
SSLYRYRSRS GRTALSEEEE EELELRKLFP LHEKDFADIL MEPTLEEKKK VSDGREEEAA 3600
PDPTLLCQSS MQAVMLIHQQ LCLSFARSLW YQQAVPPHEA KHYLSLFLSC YQTGASLVTH 3660
FYPLMGVELN DQLLGSQLLA CTLSSNTLCG EATSDLMMRP DGPYDFYQHP NVAEARQCQP 3720
VLQGFSEAVS QLLQDWPEHP VLQQLLVVMD RIRGFPLSSP ISKFLNGLEI LLAKAQDWEE 3780
NASRVLSLRK HLDLVSQMII RWRKLELNCW SMSLDNTMIR HTEKSTKHWF SIYQMLEKHM 3840
QERTEEQEDD KQMTLMLLVS TLQAFIEGSS LGEFHVRLQM LLVFHCHVLL MPQVEGKDSL 3900
CSVLWNLYHF YKQFLDPVKA KIMELRSPIE KELKEFVKIS KWNDVSFWSI KQSVEKTHRT 3960
LFKFMKKFEA VLSEPCQSCL VESDKEEQPD CLPKPTEEAT METSPIQGLN NALRETLLAQ 4020
PVEWKPSGTE QCQDASPLSV EGELLRRLPR LSKRMRKMCL VFMKESPLPH LVESLDQFTG 4080
GVISSVSELQ SLKVDPSAEK EKQHSEAKHI LLQKHRALSD LFKHLANIGL SYRKGLAWAR 4140
SKSPQELLHL HPLDLRSALS IVSSTREADS RLLTEISSLW DGCQKYFYRS LARHTRLTAA 4200
LATPVKEVSM GTIERCKGFS AHLMKLLIRQ RHSLTTLTEQ WIILRNLLSC VQEIHSRLTG 4260
PPVYPVAFPP QDSVQQWTER LQHLAMQSQI LLEQFSWLFQ CCPSAEPTVG HRDAQVQEHP 4320
SASHLENIDF KETIAGVMPD LLSSDLSYPS PVPTSQLPSA CRMRRQDQLW QQSTAGLTEM 4380
LKTIKTMKAG VDKIRQQSCE TLFHTWEDFE VCSSGLNCLS QVSAHLQGLA SLFILPGIEV 4440
EQTDSRMALV ESLDYLRGEV SKAIDDFTAW KARLFVAHKQ EGNQMVEESF VEDFSEQVET 4500
AIRAILCTIQ NLAERNNKKA EDSAVDKRLQ EEDGGKEEEA SFKSLQPGHL TKLLEDDFWA 4560
SVSTLHVQKI ISSVSELLER LKSCSEDGNT TKHKVFSQSC GLLVRLIPIL CGFSDLVLFF 4620
LTVSLATHRS TAKLLSVLAQ TFTELSQKGF CLPKELMEDS AGEGATQFHD YEGGGIGDGE 4680
GMKDVSDRIE NEEQVEDTFQ KGQEKDEEDL DSKPDTKGED NAIEMSEDFD GKMHDGELEQ 4740
EEDDEKSDSE DGDLDKQMGN LNGEEADKLD ERLWGDDEEE DEDGDGRAEE TGPGVDEEDS 4800
ELVAKDDSLD AGNLNKNKKH QDEKEDSEPE DVEQGQEKIN EQIDEREYDE NEVDPYHGNQ 4860
EKLPEPEALD LPDDLKLDSE DKSGGEDTDN EEAEEENPLE IKEKTVDMEE TDHEIEEPGA 4920
GQDEGESPHE PEEGPSEDKE NMDMDTGADD QDRDTSSHAE EHSLEEEAEE EEEKGEKEED 4980
KATTDGGGES GVNPVDQGLQ PQKEEEEEGE QSDAEEQVPE ATERKEHATC GQTGVDNVQS 5040
AQAVELAGAA PEKEQGKEEH GSGAADANQA EGHESNLIAR LSSQQHTNKN TQSFKRRPGQ 5100
ADNERSVGDY NERVRKRLRT VGTDRETEQE PTQAQVEDAD AFEHVKQGSD AYDAQTYDVA 5160
SSEQQQTAKA SGQDQEEEEI EDILMDTEEE LMRAEDTEQL KPEAVQSETA ATSGSSEMEV 5220
DMQTLKTKED QDPRTTTPHQ ETENERPERS RDSTIHTLRQ FLVDSVFQPI LKDISELRQE 5280
MERQLETWQA HDYGNAEEEK AAAEMWQNYL VLTASLSQQL CEQLRLLLEP TQAAKLRGDY 5340
RTGKRLNMRK IIPYIASQFR KDRIWLRRTK PSKRQYQICL AIDDSSSMVD NHTKQLAFES 5400
LAVIGNALTL LEVGQIAVCS FGESVKLLHP FHEQFNDSSG THILRLCTFQ QRKTKIAQFL 5460
ETVAKMFAAA QKLSQNVSPE TAQLLLIVSD GRGLFLEGKD RVLAAVQAAQ NANIFVIFVV 5520
LDNPNSRDSI LDIKVPIFKG PGEMPEIRSY MEEFPFPFYI ILRDVNALPE TLSDALRQWF 5580
ELVTASDHS 5589 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0006461; P:protein complex assembly; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR012099; Midasin.
 IPR027417; P-loop_NTPase.
 IPR002035; VWF_A. 
Pfam
 PF07728; AAA_5 
SMART
 SM00382; AAA
 SM00327; VWA 
PROSITE
 PS50234; VWFA 
PRINTS