CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004475
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 
Protein Synonyms/Alias
 GMP-PDE alpha; PDE V-B1 
Gene Name
 PDE6A 
Gene Synonyms/Alias
 PDEA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84CIFNVMKKLCFLLQAmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 
Functional Description
 This protein participates in processes of transmission and amplification of the visual signal. 
Sequence Annotation
 DOMAIN 73 222 GAF 1.
 DOMAIN 254 431 GAF 2.
 ACT_SITE 559 559 Proton donor (By similarity).
 METAL 563 563 Divalent metal cation 1 (By similarity).
 METAL 599 599 Divalent metal cation 1 (By similarity).
 METAL 600 600 Divalent metal cation 1 (By similarity).
 METAL 600 600 Divalent metal cation 2 (By similarity).
 METAL 720 720 Divalent metal cation 1 (By similarity).
 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 857 857 Cysteine methyl ester (By similarity).
 LIPID 857 857 S-farnesyl cysteine (By similarity).  
Keyword
 Acetylation; Cell membrane; cGMP; Complete proteome; Disease mutation; Hydrolase; Lipoprotein; Membrane; Metal-binding; Methylation; Polymorphism; Prenylation; Reference proteome; Repeat; Retinitis pigmentosa; Sensory transduction; Vision. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 860 AA 
Protein Sequence
MGEVTAEEVE KFLDSNIGFA KQYYNLHYRA KLISDLLGAK EAAVDFSNYH SPSSMEESEI 60
IFDLLRDFQE NLQTEKCIFN VMKKLCFLLQ ADRMSLFMYR TRNGIAELAT RLFNVHKDAV 120
LEDCLVMPDQ EIVFPLDMGI VGHVAHSKKI ANVPNTEEDE HFCDFVDILT EYKTKNILAS 180
PIMNGKDVVA IIMAVNKVDG SHFTKRDEEI LLKYLNFANL IMKVYHLSYL HNCETRRGQI 240
LLWSGSKVFE ELTDIERQFH KALYTVRAFL NCDRYSVGLL DMTKQKEFFD VWPVLMGEVP 300
PYSGPRTPDG REINFYKVID YILHGKEDIK VIPNPPPDHW ALVSGLPAYV AQNGLICNIM 360
NAPAEDFFAF QKEPLDESGW MIKNVLSMPI VNKKEEIVGV ATFYNRKDGK PFDEMDETLM 420
ESLTQFLGWS VLNPDTYESM NKLENRKDIF QDIVKYHVKC DNEEIQKILK TREVYGKEPW 480
ECEEEELAEI LQAELPDADK YEINKFHFSD LPLTELELVK CGIQMYYELK VVDKFHIPQE 540
ALVRFMYSLS KGYRKITYHN WRHGFNVGQT MFSLLVTGKL KRYFTDLEAL AMVTAAFCHD 600
IDHRGTNNLY QMKSQNPLAK LHGSSILERH HLEFGKTLLR DESLNIFQNL NRRQHEHAIH 660
MMDIAIIATD LALYFKKRTM FQKIVDQSKT YESEQEWTQY MMLEQTRKEI VMAMMMTACD 720
LSAITKPWEV QSQVALLVAA EFWEQGDLER TVLQQNPIPM MDRNKADELP KLQVGFIDFV 780
CTFVYKEFSR FHEEITPMLD GITNNRKEWK ALADEYDAKM KVQEEKKQKQ QSAKSAAAGN 840
QPGGNPSPGG ATTSKSCCIQ 860 
Gene Ontology
 GO:0097381; C:photoreceptor disc membrane; TAS:Reactome.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IMP:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0051480; P:cytosolic calcium ion homeostasis; IMP:BHF-UCL.
 GO:0046037; P:GMP metabolic process; IMP:BHF-UCL.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro.
 GO:0007601; P:visual perception; TAS:ProtInc. 
Interpro
 IPR003018; GAF.
 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 
Pfam
 PF01590; GAF
 PF00233; PDEase_I 
SMART
 SM00065; GAF
 SM00471; HDc 
PROSITE
 PS00126; PDEASE_I 
PRINTS
 PR00387; PDIESTERASE1.