CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006730
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynein heavy chain, cytoplasmic 
Protein Synonyms/Alias
 Dynein heavy chain, cytosolic; DYHC 
Gene Name
 Dhc64C 
Gene Synonyms/Alias
 cDhc; CG7507 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1377YESYEYVKKLIQSYIacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. 
Sequence Annotation
 NP_BIND 1895 1902 ATP (Potential).
 NP_BIND 2210 2217 ATP (Potential).
 NP_BIND 2580 2587 ATP (Potential).
 NP_BIND 2922 2929 ATP (Potential).
 REGION 1 1856 Stem (By similarity).
 REGION 1857 2084 AAA 1 (By similarity).
 REGION 2166 2437 AAA 2 (By similarity).
 REGION 2541 2790 AAA 3 (By similarity).
 REGION 2884 3153 AAA 4 (By similarity).
 REGION 3189 3478 Stalk (By similarity).
 REGION 3539 3768 AAA 5 (By similarity).
 REGION 3989 4205 AAA 6 (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Microtubule; Motor protein; Nucleotide-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4639 AA 
Protein Sequence
MGDSLENPDT SVDPIVNLSI ANYDAFANYL RKAVTILLPE DDVVPASLND ALDDPVNQDT 60
IRKFLSDPQV QALYVQRNCI KEDDSEQPAE GEDEKEQVTY QISNDVHFTN SRMASLACIK 120
RGLVVEADKS IHSQLRLINF SDGSPYETLH AFISKSLAPY FKSYVKESGR ADRDGDKMAP 180
SVEKKLAELE MGLLHLQQNI DIPEITLTAH QTVNNVIRKC AEENRKAKVA DFGDKVEDSS 240
FLNLLQNGVN RWIAEIKKVT KLNRDPGSGT ALQEISFWLN LERALYRIQE KRESPEVALT 300
LDILKHGKRF HATVSFDTDT GLKQALATVA DYNPLMKDFP INDLLSATEL EKIRPAVQQI 360
FAHLRKVRNT KYPIQRCLKL IEAISRDLSQ QLLKVLGTRR LMHIPFDEFE RVMNQCFEIF 420
SCWDDEYDKL QGLLRDIVKK KRDEHLKMVW RVSPAHKKLQ TRMEHMRKFR RQHEQLRTVI 480
LRVLRPTKPA VGDDGNVVET KQPYSLDAAD ANAIEEVNLA YENVKEVDCL DITKEGSEAW 540
EAAVKRYEEK IDRVETRITA HLRDQLGTAK NANEMFRIFS RFNALFVRPH IRGAIREYQT 600
QLIQRVKDDI EALHEKFKVQ YPQSKSCRLS SVRDLPPVAG SIIWARQIDN QLTMYLKRVE 660
DVLGKGWETH IEGQKLKADG DSFRAKLSIS DVFHEWARKV QERNFGSTGR IFTIESTRSR 720
IGRGNVLRLR VNFLPEIITL AKEVRNIKNL GFRVPLTIVN KAHQANQIYP YAISLIESVR 780
TYERTLEKIE DRASIVPLVA GLRKDVLNLV SEGIGLIWES YKLDPYVIRL SECVTQFQEK 840
VDDLLVVEEQ LDVDVRSLET CPYSAATFVE ILSKIQHAVD DLSLRQYSNL SVWVTRLDEE 900
VEKKLALRLQ AGIQAWTEAL TGNKKEVDTS MDTDAPAQPT HKLGGDPQIQ NAVHEIRITN 960
QQMYLYPSIE EARFQIMQQF FAWQAIVTSQ VRLQSTRYQV GLEKHVSQTY RNLLTKLPEG 1020
KILENAYGAI EQKVSEVRNY VDEWLRYQSL WDLQADMLYG RLGEDVNLWI KCLNDIKQSR 1080
TTFDTSDTRR AYGPIIIDYA KVQAKVTLKY DSWHKEALGK FGTLLGTEMT SFHSKVSKSR 1140
TDLEMQSIEA ASTSDAVSFI TYVQSLKKDM IAWDKQVEVF REAQRILERQ RFQFPNTWLH 1200
VDNIEGEWSA FNEIIKRKDT AIQTQVASLQ AKIVAEDKAV ETRTVDFLND WEKTKPTGGK 1260
IRPDDALQQL QIFESKYSRL KEERDNVVKA KEALELQESA VPNNSAERMN VALEELQDLR 1320
GVWSELSKVW TQIDETREKP WLSVQPRKLR QQLEAMMAQL KELPARLRMY ESYEYVKKLI 1380
QSYIKVNMLI VELKSDALKE RHWKQLTKQL RVNWVLSDLS LGQVWDVNLQ KNEGIVKDII 1440
LVAQGEMALE EFLKQVRESW QNYELDLINY QNKCRIIRGW DDLFNKVKEH INSVAAMKLS 1500
PYYKVFEEEA LTWEEKLNRI NALFDVWIDV QRRWVYLEGI FSGSADIKTL LPVETSRFQS 1560
ISSEFLGLMK KVTKSPKVMD VLNIPAVQRS LERLADLLGK IQKALGEYLE RERTSFPRFY 1620
FVGDEDLLEI IGNSKNIARL QKHFKKMFAG VAAILLNEEN NVILGISSRE GEEVHFMNPV 1680
STVEHPKINE WLSLVEKQMR FTLASLLAQA VQDIKQFRDG KIDPQAYMEW CDKYQAQIVV 1740
LAAQILWSED VESALQQASE NNQSKPMQRV LGNVESTLNV LADSVLQEQP PLRRRKLEHL 1800
INEFVHKRTV TRRLLNNGVT SPKSFQWLCE MRFYFDPRQT EVLQQLTIHM ANARFFYGFE 1860
YLGVQDRLVQ TPLTDRCYLT MTQALESRLG GSPFGPAGTG KTESVKALGN QLGRFVLVFN 1920
CDETFDFQAM GRIFVGLCQV GAWGCFDEFN RLEERMLSAC SQQIQTIQEA LKYEMDSNKE 1980
SITVELVGKQ VRVSPDMAIF ITMNPGYAGR SNLPDNLKKL FRSLAMTTPD RQLIAEVMLF 2040
SQGFRSAEKL ACKIVPFFKL CDEQLSNQSH YDFGLRALKS VLISAGNVKR DRIMKIKEQM 2100
KQRGDENIDE ASVAENLPEQ EILIQSVCET MVPKLVAEDI PLLFSLLSDV FPNVGYTRAE 2160
MKGLKEEIRK VCQEDYLVCG EGDEQGAAWM EKVLQLYQIS NLNHGLMMVG PSGSGKSTAW 2220
KTLLKALERF EGVEGVAHVI DPKAISKEAL YGVLDPNTRE WTDGLFTHIL RKIIDNVRGE 2280
INKRQWIIFD GDVDPEWVEN LNSVLDDNKL LTLPNGERLS LPPNVRVMFE VQDLKFATLA 2340
TVSRCGMVWF SEDVLSTEMI FENYLSRLRS IPLEDGDEDF VGVIKPAKDK EEEVSPSLQV 2400
QRDIALLLLP FFSADGIVVR TLEYAMDQEH IMDFTRLRAL SSLFSMLNQA ARNVLTFNAQ 2460
HPDFPCSADQ LEHYIPKALV YSVLWSFAGD AKLKVRIDLG DFVRSVTTVP LPGAAGAPII 2520
DYEVNMSGDW VPWSNKVPVI EVETHKVASP DIVVPTLDTV RHESLLYTWL AEHKPLVLCG 2580
PPGSGKTMTL FSALRALPDM EVVGLNFSSA TTPELLLKTF DHYCEYRKTP NGVVLSPVQI 2640
GKWLVLFCDE INLPDMDSYG TQRVISFLRQ LVEHKGFYRA SDQAWVSLER IQFVGACNPP 2700
TDPGRKPLSH RFLRHVPIIY VDYPGETSLK QIYGTFSRAM LRLMPALRGY AEPLTNAMVE 2760
FYLASQDRFT QDMQPHYVYS PREMTRWVRG ICEAIRPLDS LPVEGLVRLW AHEALRLFQD 2820
RLVDDSERRW TNENIDLVGQ KHFPGINQEE ALQRPILYSN WLSKDYMPVN REELREYVHA 2880
RLKVFYEEEL DVPLVLFDEV LDHVLRIDRI FRQPQGHLLL IGVSGAGKTT LSRFVAWMNG 2940
LSIFQIKVHN KYTSEDFDED LRCVLRRSGC KDEKIAFILD ESNVLDSGFL ERMNTLLANG 3000
EVPGLFEGDE YTTLMTQCKE GAQREGLMLD SSDELYKWFT QQVMRNLHVV FTMNPSTDGL 3060
KDRAATSPAL FNRCVLNWFG DWSDSALFQV GKEFTTRVDL EKPNWHAPDF FPSVCPLVPA 3120
NPTHRDAVIN SCVYVHQTLH QANARLAKRG GRTMAVTPRH YLDFIHHFVK LYNEKRSDLE 3180
EQQLHLNVGL NKIAETVEQV EEMQKSLAVK KQELQAKNEA ANAKLKQMFQ DQQEAEKKKI 3240
QSQEIQIRLA DQTVKIEEKR KYVMADLAQV EPAVIDAQAA VKSIRKQQLV EVRTMANPPS 3300
VVKLALESIC LLLGENATDW KSIRAVIMRE NFINSIVSNF GTENITDDVR EKMKSKYLSN 3360
PDYNFEKVNR ASMACGPMVK WAIAQIEYAD MLKRVEPLRE ELRSLEEQAD VNLASAKETK 3420
DLVEQLERSI AAYKEEYAQL ISQAQAIKTD LENVQAKVDR SIALLKSLNI ERERWESTSE 3480
TFKSQMSTII GDVLLSAAFI AYGGYFDQHY RLNLFTTWSQ HLQAASIQYR ADIARTEYLS 3540
NPDERLRWQA NALPTDDLCT ENAIMLKRFN RYPLIIDPSG QATTFLLNEY AGKKITKTSF 3600
LDDSFRKNLE SALRFGNPLL VQDVENYDPI LNPVLNRELR RTGGRVLITL GDQDIDLSPS 3660
FVIFLSTRDP TVEFPPDICS RVTFVNFTVT RSSLQSQCLN QVLKAERPDI DEKRSDLLKL 3720
QGEFRLRLRQ LEKSLLQALN DAKGKILDDD SVITTLETLK KEAYDINQKV DETDKVIAEI 3780
ETVSQQYLPL SVACSNIYFT MDSLNQVHFL YQYSLKMFLD IFSTVLYNNP KLEGRTDHSE 3840
RLGIVTRDLF QVCYERVARG MIHIDRLTFA LLMCKIHLKG TSESNLDAEF NFFLRSREGL 3900
LANPTPVEGL SAEQIESVNR LALRLPIFRK LLEKVRSIPE LGAWLQQSSP EQVVPQLWDE 3960
SKALSPIASS VHQLLLIQAF RPDRVIAAAH NVVNTVLGED FMPNAEQELD FTSVVDKQLN 4020
CNTPALLCSV PGFDASGRVD DLAAEQNKQI SSIAIGSAEG FNQAERAINM ACKTGRWVLL 4080
KNVHLAPQWL VQLEKKMHSL QPHSGFRLFL TMEINPKVPV NLLRAGRIFV FEPPPGIRAN 4140
LLRTFSTVPA ARMMKTPSER ARLYFLLAWF HAIVQERLRY VPLGWAKKYE FNESDLRVAC 4200
DTLDTWIDTT AMGRTNLPPE KVPWDALVTL LSQSIYGGKI DNDFDQRLLT SFLKKLFTAR 4260
SFEADFALVA NVDGASGGLR HITMPDGTRR DHFLKWIENL TDRQTPSWLG LPNNAEKVLL 4320
TTRGTDLVSK LLKMQQLEDD DELAYSVEDQ SEQSAVGRGE DGRPSWMKTL HNSATAWLEL 4380
LPKNLQVLKR TVENIKDPLY RYFEREVTSG SRLLQTVILD LQDVVLICQG EKKQTNHHRS 4440
MLSELVRGII PKGWKRYTVP AGCTVIQWIT DFSNRVQQLQ KVSQLVSQAG AKELQGFPVW 4500
LGGLLNPEAY ITATRQCVAQ ANSWSLEELA LDVTITDAGL KNDQKDCCFG VTGLKLQGAQ 4560
CKNNELLLAS TIMMDLPVTI LKWIKISSEP RISKLTLPVY LNSTRTELLF TVDLAVAAGQ 4620
ESHSFYERGV AVLTSTALN 4639 
Gene Ontology
 GO:0005938; C:cell cortex; IDA:FlyBase.
 GO:0005868; C:cytoplasmic dynein complex; ISS:FlyBase.
 GO:0045169; C:fusome; TAS:FlyBase.
 GO:0045172; C:germline ring canal; TAS:FlyBase.
 GO:0005794; C:Golgi apparatus; IDA:FlyBase.
 GO:0000776; C:kinetochore; IDA:FlyBase.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0030529; C:ribonucleoprotein complex; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042623; F:ATPase activity, coupled; IDA:FlyBase.
 GO:0003777; F:microtubule motor activity; IDA:FlyBase.
 GO:0008088; P:axon cargo transport; IMP:FlyBase.
 GO:0007098; P:centrosome cycle; IMP:FlyBase.
 GO:0051642; P:centrosome localization; IMP:FlyBase.
 GO:0040003; P:chitin-based cuticle development; IGI:FlyBase.
 GO:0007282; P:cystoblast division; IMP:FlyBase.
 GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
 GO:0045198; P:establishment of epithelial cell apical/basal polarity; IDA:FlyBase.
 GO:0051683; P:establishment of Golgi localization; IMP:FlyBase.
 GO:0040001; P:establishment of mitotic spindle localization; TAS:FlyBase.
 GO:0007301; P:female germline ring canal formation; TAS:FlyBase.
 GO:0048134; P:germ-line cyst formation; TAS:FlyBase.
 GO:0007294; P:germarium-derived oocyte fate determination; IMP:FlyBase.
 GO:0008298; P:intracellular mRNA localization; TAS:FlyBase.
 GO:0006886; P:intracellular protein transport; IMP:FlyBase.
 GO:0051237; P:maintenance of RNA location; IDA:FlyBase.
 GO:0035011; P:melanotic encapsulation of foreign target; IMP:FlyBase.
 GO:0048311; P:mitochondrion distribution; IMP:FlyBase.
 GO:0047497; P:mitochondrion transport along microtubule; IMP:FlyBase.
 GO:0007067; P:mitosis; IMP:FlyBase.
 GO:0007052; P:mitotic spindle organization; IMP:FlyBase.
 GO:0043148; P:mitotic spindle stabilization; IMP:FlyBase.
 GO:0016319; P:mushroom body development; IMP:FlyBase.
 GO:0007405; P:neuroblast proliferation; IMP:FlyBase.
 GO:0007312; P:oocyte nucleus migration involved in oocyte dorsal/ventral axis specification; TAS:FlyBase.
 GO:0030723; P:ovarian fusome organization; IMP:FlyBase.
 GO:0007279; P:pole cell formation; IMP:FlyBase.
 GO:0046604; P:positive regulation of mitotic centrosome separation; IMP:FlyBase.
 GO:2001019; P:positive regulation of retrograde axon cargo transport; IMP:FlyBase.
 GO:0034501; P:protein localization to kinetochore; IMP:FlyBase.
 GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IMP:FlyBase.
 GO:0050658; P:RNA transport; IMP:FlyBase.
 GO:0034063; P:stress granule assembly; IMP:BHF-UCL. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR025290; DUF4151.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013594; Dynein_heavy_dom-1.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08385; DHC_N1
 PF08393; DHC_N2
 PF13666; DUF4151
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS