| Tag | Content |
|---|
| CPLM ID | CPLM-009494 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcium-dependent protein kinase 1 |
Protein Synonyms/Alias | |
Gene Name | CPK1 |
Gene Synonyms/Alias | CDPK1; PFB0815w |
Created Date | July 27, 2013 |
Organism | Plasmodium falciparum (isolate 3D7) |
NCBI Taxa ID | 36329 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 408 | YNILRSFKNELGELK | acetylation | [1] |
|
Reference | [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development. Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L. Mol Microbiol. 2013 Aug;89(4):660-75. [ PMID: 23796209] |
Functional Description | Calcium-dependent kinase which may phosphorylate proteins of the host erythrocyte membranes (By similarity). |
Sequence Annotation | DOMAIN 56 325 Protein kinase.
DOMAIN 372 407 EF-hand 1.
DOMAIN 416 451 EF-hand 2.
DOMAIN 452 487 EF-hand 3.
DOMAIN 486 521 EF-hand 4.
NP_BIND 62 70 ATP (By similarity).
ACT_SITE 191 191 Proton acceptor (By similarity).
BINDING 85 85 ATP (By similarity).
LIPID 2 2 N-myristoyl glycine (Potential). |
Keyword | ATP-binding; Calcium; Complete proteome; Kinase; Lipoprotein; Membrane; Metal-binding; Myristate; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 524 AA |
Protein Sequence | MGCSQSSNVK DFKTRRSKFT NGNNYGKSGN NKNSEDLAIN PGMYVRKKEG KIGESYFKVR 60
KLGSGAYGEV LLCREKHGHG EKAIKVIKKS QFDKMKYSIT NKIECDDKIH EEIYNEISLL 120
KSLDHPNIIK LFDVFEDKKY FYLVTEFYEG GELFEQIINR HKFDECDAAN IMKQILSGIC 180
YLHKHNIVHR DIKPENILLE NKHSLLNIKI VDFGLSSFFS KDNKLRDRLG TAYYIAPEVL 240
RKKYNEKCDV WSCGVILYIL LCGYPPFGGQ NDQDIIKKVE KGKYYFDFND WKNISEEAKE 300
LIKLMLTYDY NKRITAKEAL NSKWIKKYAN NINKSDQKTL CGALSNMRKF EGSQKLAQAA 360
ILFIGSKLTT LEERKELTDI FKKLDKNGDG QLDKKELIEG YNILRSFKNE LGELKNVEEE 420
VDNILKEVDF DKNGYIEYSE FISVCMDKQI LFSEERLRDA FNLFDTDKSG KITKEELANL 480
FGLTSISEQM WNEVLGEADK NKDNMIDFDE FVNMMHKICD NKSS 524 |
Gene Ontology | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |