CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031387
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caseinolytic peptidase B protein homolog 
Protein Synonyms/Alias
 cDNA FLJ53238, highly similar to Caseinolytic peptidase B protein 
Gene Name
 CLPB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
112AREGEVMKLLRTSEAubiquitination[1]
240EEGGQLTKKLKQCPNubiquitination[1]
388KELNFWAKRAKQRHNubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 506 AA 
Protein Sequence
MVAAINRNNS VVQVLLAAGA DPNLGDDFSS VYKTAKEQGI HSLEVLITRE DDFNNRLNNR 60
ASFKGCTALH YAVLADDYRT VKELLDGGAN PLQRNEMGHT PLDYAREGEV MKLLRTSEAK 120
YQEKQRKREA EERRRFPLEQ RLKEHIIGQE SAIATVGAAI RRKENGWYDE EHPLVFLFLG 180
SSGIGKTELA KQTAKYMHKD AKKGFIRLDM SEFQERHEVA KFIGSPPGYV GHEEGGQLTK 240
KLKQCPNAVV LFDEVDKAHP DVLTIMLQLF DEGRLTDGKG KTIDCKDAIF IMTSNVASDE 300
IAQHALQLRQ EALEMSRNRI AENLGDVQIS DKITISKNFK ENVIRPILKA HFRRDEFLGR 360
INEIVYFLPF CHSELIQLVN KELNFWAKRA KQRHNITLLW DREVADVLVD GYNVHYGARS 420
IKHEVERRVV NQLAAAYEQD LLPGGCTLRI TVEDSDKQLL KSPELPSPQA EKRLPKLRLE 480
IIDKDSKTRR LDIRAPLHPE KVCNTI 506 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR013093; ATPase_AAA-2.
 IPR001270; Chaprnin_ClpA/B.
 IPR019489; Clp_ATPase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07724; AAA_2
 PF12796; Ank_2
 PF10431; ClpB_D2-small 
SMART
 SM00382; AAA
 SM00248; ANK
 SM01086; ClpB_D2-small 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT 
PRINTS
 PR00300; CLPPROTEASEA.