| Tag | Content |
|---|
| CPLM ID | CPLM-012418 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nuclear receptor subfamily 1 group D member 2 |
Protein Synonyms/Alias | Orphan nuclear hormone receptor BD73; Rev-erb-beta; V-erbA-related protein 1-related; EAR-1R |
Gene Name | NR1D2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 162 | RCQQCRFKKCLSVGM | acetylation | [1] | | 163 | CQQCRFKKCLSVGMS | acetylation | [1] |
|
Reference | [1] The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. Wang J, Liu N, Liu Z, Li Y, Song C, Yuan H, Li YY, Zhao X, Lu H. Biochim Biophys Acta. 2008 Feb;1783(2):224-36. [ PMID: 17996965] |
Functional Description | Binds to the sequences 5'-AATGTAGGTCA-3' and 5'- ATAACTAGGTCA-3'. Acts as a potent competitive repressor of ROR alpha function (By similarity). |
Sequence Annotation | DNA_BIND 100 176 Nuclear receptor.
ZN_FING 103 123 NR C4-type.
ZN_FING 140 164 NR C4-type. |
Keyword | 3D-structure; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 579 AA |
Protein Sequence | MEVNAGGVIA YISSSSSASS PASCHSEGSE NSFQSSSSSV PSSPNSSNSD TNGNPKNGDL 60
ANIEGILKND RIDCSMKTSK SSAPGMTKSH SGVTKFSGMV LLCKVCGDVA SGFHYGVHAC 120
EGCKGFFRRS IQQNIQYKKC LKNENCSIMR MNRNRCQQCR FKKCLSVGMS RDAVRFGRIP 180
KREKQRMLIE MQSAMKTMMN SQFSGHLQND TLVEHHEQTA LPAQEQLRPK PQLEQENIKS 240
SSPPSSDFAK EEVIGMVTRA HKDTFMYNQE QQENSAESMQ PQRGERIPKN MEQYNLNHDH 300
CGNGLSSHFP CSESQQHLNG QFKGRNIMHY PNGHAICIAN GHCMNFSNAY TQRVCDRVPI 360
DGFSQNENKN SYLCNTGGRM HLVCPLSKSP YVDPHKSGHE IWEEFSMSFT PAVKEVVEFA 420
KRIPGFRDLS QHDQVNLLKA GTFEVLMVRF ASLFDAKERT VTFLSGKKYS VDDLHSMGAG 480
DLLNSMFEFS EKLNALQLSD EEMSLFTAVV LVSADRSGIE NVNSVEALQE TLIRALRTLI 540
MKNHPNEASI FTKLLLKLPD LRSLNNMHSE ELLAFKVHP 579 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0004879; F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; TAS:UniProtKB. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003707; F:steroid hormone receptor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006367; P:transcription initiation from RNA polymerase II promoter; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |