UniProt Accession

 Q3U4N2_MOUSE; Q3U4N2 

Genbank Protein ID

 AL611985; BC110695; AK154135; CH466594 

Genbank Nucleotide ID

 AAI10696.1; BAE32399.1; EDL14933.1 

Protein Name

 Icmt protein 

Protein Synonyms/Alias

 Isoprenylcysteine carboxyl methyltransferase, isoform CRA_a; Protein-S-isoprenylcysteine O-methyltransferase 

Gene Name

 Icmt 

Gene Synonyms/Alias

 mCG_12314 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
278	PTGLPFIKGVKVEL*	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Methyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0008140; F:cAMP response element binding protein binding; IMP:MGI.
 GO:0004671; F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0035264; P:multicellular organism growth; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0046578; P:regulation of Ras protein signal transduction; IGI:MGI. 

Interpro

 IPR007269; ICMT_MeTrfase.
 IPR025770; PPMT_MeTrfase. 

Pfam

 PF04140; ICMT 

SMART

  

PROSITE

 PS51564; SAM_ICMT 

PRINTS