| Tag | Content |
|---|
| CPLM ID | CPLM-000458 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA-directed RNA polymerase I subunit RPA34 |
Protein Synonyms/Alias | A34.5; Antisense to ERCC-1 protein; ASE-1; CD3-epsilon-associated protein; CAST; CD3E-associated protein; RNA polymerase I-associated factor PAF49 |
Gene Name | CD3EAP |
Gene Synonyms/Alias | ASE1; CAST; PAF49 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 270 | EPEDKTVKQEQINTE | sumoylation | [1] |
|
Reference | [1] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC. Mol Cell. 2010 Aug 27;39(4):641-52. [ PMID: 20797634] |
Functional Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. |
Sequence Annotation | MOD_RES 1 1 N-acetylmethionine.
MOD_RES 27 27 Phosphoserine.
MOD_RES 80 80 Phosphotyrosine.
MOD_RES 128 128 Phosphoserine.
MOD_RES 136 136 Phosphoserine.
MOD_RES 172 172 Phosphoserine.
MOD_RES 205 205 Phosphoserine.
MOD_RES 285 285 Phosphoserine.
MOD_RES 287 287 Phosphothreonine.
MOD_RES 309 309 Phosphoserine.
MOD_RES 490 490 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Chromosome; Complete proteome; DNA-directed RNA polymerase; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 510 AA |
Protein Sequence | MEEPQAGDAA RFSCPPNFTA KPPASESPRF SLEALTGPDT ELWLIQAPAD FAPECFNGRH 60
VPLSGSQIVK GKLAGKRHRY RVLSSCPQAG EATLLAPSTE AGGGLTCASA PQGTLRILEG 120
PQQSLSGSPL QPIPASPPPQ IPPGLRPRFC AFGGNPPVTG PRSALAPNLL TSGKKKKEMQ 180
VTEAPVTQEA VNGHGALEVD MALGSPEMDV RKKKKKKNQQ LKEPEAAGPV GTEPTVETLE 240
PLGVLFPSTT KKRKKPKGKE TFEPEDKTVK QEQINTEPLE DTVLSPTKKR KRQKGTEGME 300
PEEGVTVESQ PQVKVEPLEE AIPLPPTKKR KKEKGQMAMM EPGTEAMEPV EPEMKPLESP 360
GGTMAPQQPE GAKPQAQAAL AAPKKKTKKE KQQDATVEPE TEVVGPELPD DLEPQAAPTS 420
TKKKKKKKER GHTVTEPIQP LEPELPGEGQ PEARATPGST KKRKKQSQES RMPETVPQEE 480
MPGPPLNSES GEEAPTGRDK KRKQQQQQPV 510 |
Gene Ontology | GO:0005694; C:chromosome; IEA:UniProtKB-SubCell. GO:0005736; C:DNA-directed RNA polymerase I complex; IEA:Compara. GO:0005739; C:mitochondrion; IDA:HPA. GO:0000120; C:RNA polymerase I transcription factor complex; TAS:ProtInc. GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW. GO:0009303; P:rRNA transcription; TAS:ProtInc. GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |