UniProt Accession

 PGPI_HUMAN; Q9NXJ5; A8K1Q3 

Genbank Protein ID

 AJ278828; AK000215; AK289968; CH471106 

Genbank Nucleotide ID

 CAC03610.1; BAA91015.1; BAF82657.1; EAW84691.1 

Protein Name

 Pyroglutamyl-peptidase 1 

Protein Synonyms/Alias

 5-oxoprolyl-peptidase; Pyroglutamyl aminopeptidase I; PAP-I; Pyroglutamyl-peptidase I; PGP-I; Pyrrolidone-carboxylate peptidase 

Gene Name

 PGPEP1 

Gene Synonyms/Alias

 PGPI 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
174	VHVPPLGKPYNADQL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Removes 5-oxoproline from various penultimate amino acid residues except L-proline. 

Sequence Annotation

 ACT_SITE 85 85 By similarity.
 ACT_SITE 149 149 By similarity.
 ACT_SITE 168 168 By similarity.  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Protease; Reference proteome; Thiol protease. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR000816; Peptidase_C15.
 IPR016125; Peptidase_C15-like. 

Pfam

 PF01470; Peptidase_C15 

SMART

  

PROSITE

 PS01334; PYRASE_CYS
 PS01333; PYRASE_GLU 

PRINTS

 PR00706; PYROGLUPTASE.