UniProt Accession

 PRP4B_HUMAN; Q13523; A8K5C9; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6 

Genbank Protein ID

 AY029347; AF283465; AB011108; AK291244; AL138831; AL033383; AL033383; AL138831; CH471087; BC009844; BC034969; U48736 

Genbank Nucleotide ID

 AAK38155.1; AAM19101.1; BAA25462.1; BAF83933.1; CAI20480.1; CAI20480.1; CAI42121.1; CAI42121.1; EAW55146.1; AAH09844.1; AAH34969.1; AAB03268.1 

Protein Name

 Serine/threonine-protein kinase PRP4 homolog 

Protein Synonyms/Alias

 PRP4 kinase; PRP4 pre-mRNA-processing factor 4 homolog 

Gene Name

 PRPF4B 

Gene Synonyms/Alias

 KIAA0536; PRP4; PRP4H; PRP4K 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
358	KRRSLSPKPRDKSRR	acetylation	[1]
717	ANQEVAVKIIRNNEL	acetylation	[1]
905	LKLAMDLKGKMPNKM	acetylation	[1]
907	LAMDLKGKMPNKMIR	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. 

Sequence Annotation

 DOMAIN 687 1006 Protein kinase.
 NP_BIND 693 701 ATP (By similarity).
 ACT_SITE 815 815 Proton acceptor (By similarity).
 BINDING 717 717 ATP (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 23 23 Phosphoserine.
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 87 87 Phosphoserine.
 MOD_RES 93 93 Phosphoserine.
 MOD_RES 140 140 Phosphotyrosine.
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 144 144 Phosphoserine.
 MOD_RES 239 239 Phosphoserine.
 MOD_RES 241 241 Phosphoserine.
 MOD_RES 257 257 Phosphoserine.
 MOD_RES 277 277 Phosphoserine.
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 292 292 Phosphoserine (By similarity).
 MOD_RES 294 294 Phosphoserine.
 MOD_RES 328 328 Phosphoserine.
 MOD_RES 354 354 Phosphoserine.
 MOD_RES 356 356 Phosphoserine.
 MOD_RES 366 366 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.
 MOD_RES 385 385 Phosphothreonine.
 MOD_RES 387 387 Phosphoserine.
 MOD_RES 427 427 Phosphoserine.
 MOD_RES 431 431 Phosphoserine.
 MOD_RES 437 437 Phosphoserine.
 MOD_RES 518 518 Phosphoserine.
 MOD_RES 519 519 Phosphoserine.
 MOD_RES 520 520 Phosphoserine.
 MOD_RES 565 565 Phosphoserine.
 MOD_RES 569 569 Phosphoserine.
 MOD_RES 578 578 Phosphoserine.
 MOD_RES 580 580 Phosphoserine.
 MOD_RES 717 717 N6-acetyllysine.
 MOD_RES 849 849 Phosphotyrosine.
 MOD_RES 852 852 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Kinase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Spliceosome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1007 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005694; C:chromosome; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; TAS:ProtInc.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS