CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041788
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA repair protein RAD50 
Protein Synonyms/Alias
 RAD50 homolog (S. cerevisiae) 
Gene Name
 Rad50 
Gene Synonyms/Alias
 rCG_34232 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1089EEEILHFKKELREPQacetylation[1]
1134TLDHAIMKFHSMKMEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1312 AA 
Protein Sequence
MSRIEKMSIL GVRSFGIEDK DKQIISFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG 60
TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GEMVLVQRSM LCSQKSKKTE FKTLEGVITR 120
IKHGEKVSLS SKCAEIDREM ISCLGVSKSV LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF 180
SATRYIKALD TLRQVRQTQG QKVKECQTEL KYLRQNKEKA CEIRDQITSK EAQLASSREI 240
VKAYENELEP LKNRLKEIEH NLSKIMRLDN EIKALDSRKK QMEKDNSELE QKMEKVFQGT 300
DEQLNDLYHN HQRTVREKER RLVDCQRELE KLSKEARLLN QERAELLVEQ GRLQLQADRH 360
QEHIRARDSL IQSLAAHLEL DGFERGPFSE RQIKNFHELV RERQEREAKT ASQLLSDLTD 420
KEALKQRQMD EMRDKKSGLG RMIELKTEIL TKKQTELRNV RNELQQLEGS SDRILELDQE 480
LTKAERELSK AEKNSSIETL KAEILNLQSE KADLDRNLRK LDQEMEQLNH HTTTRTQMEM 540
LTKDKTDKDE QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE 600
LASAEQNKNH INNELKKKEE QLSSYEDKLF DVCGSQDFES DLDRLKEDIE KSSKQRAMLA 660
GATAVYSQFI TQLTDENQSC CPVCQRVFQT EAELQEVISD LQSKLRLAPD KLKSTESELK 720
KKERRRDEML GLVPMRQSII DLKEKEIPEL RNRLQSVNRD IQRLKNDIEE QETLLGTVMP 780
EEESAKVCLT DVTIMERFQM ELKDVERKIA QQAAKLQGVD LDRTVQQVNQ EKQEKQHKLD 840
TVSSKIELNR KLIQDQQEQI QHLKSKTNEL KSEKLQIATN LQRRQQMEEQ TVELSTEVQS 900
LNREIKDAKE QINPLEIALE KLQQEKEELI HRKNTSNKMA QDKINDIKEK VKNIHGYMKD 960
IENYIQDGKD DYKKQKETEL NEVVIQLNEC DKHKEKINKE MGTMRQDIDT QKIQERWLQD 1020
NLTLRKRREE LKEVEEERKQ HLKEMGQMQV LQMKNEHQKL EENIDTIKRN HSLALGRQKG 1080
YEEEILHFKK ELREPQFRDA EEKYREMMIV MRTTELVNKD LDIYYKTLDH AIMKFHSMKM 1140
EEINKIIRDL WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR 1200
CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDRE NIESLAHALV EIIKSRSQQR 1260
NFQLLVITHD EDFVELLGRS EYVEKFYRVK KNIDQCSEIV KSSINSLGSY VH 1312 
Gene Ontology
 GO:0030870; C:Mre11 complex; IEA:Compara.
 GO:0000784; C:nuclear chromosome, telomeric region; IEA:Compara.
 GO:0045120; C:pronucleus; IEA:Compara.
 GO:0008408; F:3'-5' exonuclease activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006310; P:DNA recombination; IEA:Compara.
 GO:0006302; P:double-strand break repair; IEA:Compara.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0033674; P:positive regulation of kinase activity; IEA:Compara.
 GO:0031954; P:positive regulation of protein autophosphorylation; IEA:Compara.
 GO:0000019; P:regulation of mitotic recombination; IEA:Compara.
 GO:0007004; P:telomere maintenance via telomerase; IEA:Compara. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR004584; Rad50.
 IPR007517; Rad50_Zn_hook.
 IPR013134; Zn_hook_Rad50. 
Pfam
 PF04423; Rad50_zn_hook 
SMART
  
PROSITE
 PS51131; ZN_HOOK 
PRINTS