| Tag | Content |
|---|
| CPLM ID | CPLM-024099 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase ARIH1 |
Protein Synonyms/Alias | Protein ariadne-1 homolog; ARI-1; UbcH7-binding protein; UbcM4-interacting protein 77; Ubiquitin-conjugating enzyme E2-binding protein 1 |
Gene Name | Arih1 |
Gene Synonyms/Alias | Ari; Ubch7bp; Uip77 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 140 | LSHFNWDKEKLMERY | ubiquitination | [1] | | 154 | YFDGNLEKLFAECHV | ubiquitination | [1] | | 166 | CHVINPSKKSRTRQM | ubiquitination | [1] | | 314 | ENWHDPVKCKWLKKW | ubiquitination | [1] | | 324 | WLKKWIKKCDDDSET | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation (By similarity). |
Sequence Annotation | ZN_FING 184 234 RING-type 1; atypical.
ZN_FING 254 315 IBR-type.
ZN_FING 342 373 RING-type 2.
REGION 184 252 Interaction with UBE2L3.
METAL 342 342 Zinc (By similarity).
METAL 345 345 Zinc (By similarity).
METAL 360 360 Zinc (By similarity).
METAL 365 365 Zinc (By similarity). |
Keyword | Coiled coil; Complete proteome; Cytoplasm; Ligase; Metal-binding; Reference proteome; Repeat; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 555 AA |
Protein Sequence | MDSDEGYNYE FDEDEECSEE DSGAEEEEDD DEDEPDDDNL DLGEVELVEP GLGVGGERDG 60
LLCGETGGGG GSALGPGGGG GGGGGGGGPG HEQEEDYRYE VLTAEQILQH MVECIREVNE 120
VIQNPATITR ILLSHFNWDK EKLMERYFDG NLEKLFAECH VINPSKKSRT RQMNTRSSAQ 180
DMPCQICYLN YPNSYFTGLE CGHKFCMQCW SEYLTTKIME EGMGQTISCP AHGCDILVDD 240
NTVMRLITDS KVKLKYQHLI TNSFVECNRL LKWCPAPDCH HVVKVQYPDA KPVRCKCGRQ 300
FCFNCGENWH DPVKCKWLKK WIKKCDDDSE TSNWIAANTK ECPKCHVTIE KDGGCNHMVC 360
RNQNCKAEFC WVCLGPWEPH GSAWYNCNRY NEDDAKAARD AQERSRAALQ RYLFYCNRYM 420
NHMQSLRFEH KLYAQVKQKM EEMQQHNMSW IEVQFLKKAV DVLCQCRATL MYTYVFAFYL 480
KKNNQSIIFE NNQADLENAT EVLSGYLERD ISQDSLQDIK QKVQDKYRYC ESRRRVLLQH 540
VHEGYEKDLW EYIED 555 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. GO:0008270; F:zinc ion binding; ISS:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IPI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |