UniProt Accession

 UCRI_RAT; P20788; Q6QI13 

Genbank Protein ID

 AY539946; BC085339; M24542 

Genbank Nucleotide ID

 AAS66286.1; AAH85339.1; AAA42051.1 

Protein Name

 Cytochrome b-c1 complex subunit Rieske, mitochondrial 

Protein Synonyms/Alias

 Complex III subunit 5; Cytochrome b-c1 complex subunit 5; Liver regeneration-related protein LRRGT00195; Rieske iron-sulfur protein; RISP; Ubiquinol-cytochrome c reductase iron-sulfur subunit; Cytochrome b-c1 complex subunit 11; Complex III subunit IX; Ubiquinol-cytochrome c reductase 8 kDa protein 

Gene Name

 Uqcrfs1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
46	EPPVLDVKRPFLCRE	acetylation	[1]
101	AEVLDSTKSSKESSE	acetylation	[1]
155	AMSKIEIKLSDIPEG	acetylation	[1]
163	LSDIPEGKNMAFKWR	acetylation	[1]
168	EGKNMAFKWRGKPLF	acetylation	[1]
172	MAFKWRGKPLFVRHR	acetylation	[1]
182	FVRHRTKKEIDQEAA	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. 

Sequence Annotation

 DOMAIN 187 272 Rieske.
 METAL 217 217 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 219 219 Iron-sulfur (2Fe-2S); via pros nitrogen
 METAL 236 236 Iron-sulfur (2Fe-2S) (By similarity).
 METAL 239 239 Iron-sulfur (2Fe-2S); via pros nitrogen
 DISULFID 222 238 By similarity.  

Keyword

 2Fe-2S; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Reference proteome; Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005750; C:mitochondrial respiratory chain complex III; IDA:RGD.
 GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0032403; F:protein complex binding; IDA:RGD.
 GO:0008121; F:ubiquinol-cytochrome-c reductase activity; TAS:RGD.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0046677; P:response to antibiotic; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0009725; P:response to hormone stimulus; IEP:RGD. 

Interpro

 IPR011070; Globular_prot_asu/bsu.
 IPR017941; Rieske_2Fe-2S.
 IPR014349; Rieske_Fe-S_prot.
 IPR005805; Rieske_Fe-S_prot_C.
 IPR015248; Ubiqinol_cyt_c_Rdtase_N.
 IPR006317; Ubiquinol_cyt_c_Rdtase_Fe-S-su.
 IPR004192; Ubiquinol_cyt_Rdtase_TM. 

Pfam

 PF00355; Rieske
 PF09165; Ubiq-Cytc-red_N
 PF02921; UCR_TM 

SMART

  

PROSITE

 PS51296; RIESKE 

PRINTS

 PR00162; RIESKE.