UniProt Accession

 G3V3C7_HUMAN; G3V3C7 

Genbank Protein ID

 AL355075 

Genbank Nucleotide ID

  

Protein Name

 DNA-(apurinic or apyrimidinic site) lyase 

Protein Synonyms/Alias

  

Gene Name

 APEX1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	LRTEPEAKKSKTAAK	acetylation	[1]
24	LRTEPEAKKSKTAAK	ubiquitination	[2, 3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 174 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004521; F:endoribonuclease activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0045454; P:cell redox homeostasis; IEA:Compara.
 GO:0071320; P:cellular response to cAMP; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:InterPro.
 GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Compara.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0042493; P:response to drug; IEA:Compara. 

Interpro

 IPR020847; AP_endonuclease_F1_BS.
 IPR005135; Endo/exonuclease/phosphatase.
 IPR004808; ExoDNase_III. 

Pfam

 PF03372; Exo_endo_phos 

SMART

  

PROSITE

 PS00726; AP_NUCLEASE_F1_1
 PS51435; AP_NUCLEASE_F1_4 

PRINTS