CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026706
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UvrABC system protein A 
Protein Synonyms/Alias
 UvrA protein; Excinuclease ABC subunit A 
Gene Name
 uvrA 
Gene Synonyms/Alias
 RPA2816 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
275EPADKKKKADKKVAKacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity). 
Sequence Annotation
 DOMAIN 652 984 ABC transporter (By similarity).
 NP_BIND 47 54 ATP (By similarity).
 NP_BIND 688 695 ATP (By similarity).
 ZN_FING 787 813 C4-type (By similarity).  
Keyword
 ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Membrane; Metal-binding; Nucleotide-binding; Repeat; SOS response; Transport; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1005 AA 
Protein Sequence
MDEVIKAKRQ TPAASSRTAI TIRGAREHNL KNVDVTIPRD KLVVFTGLSG SGKSSLAFDT 60
IYAEGQRRYV ESLSAYARQF LEMMQKPDVD QIDGLSPAIS IEQKTTSKNP RSTVGTVTEI 120
YDYMRLLWAR VGVPYSPATG LPIESQTVSQ MVDRVLALPE GTRLYLLAPV VRGRKGEYRK 180
ELADWLKKGF QRVKIDGAFH ELAEAPTLDK KFPHDIDVVV DRIVVRPDIG QRLAESFETA 240
LKLAEGLAVI EYADAPAAPP TAEPGQDEPA DKKKKADKKV AKIHDKSGAE RILFSEKFAC 300
PVSGFTIPEI EPRLFSFNNP YGACPECGGL GIEQHIDADL VVPDKELTLR KGAIAPWAKS 360
SSPYYLQTLT ALGKHYKFTL DTKWKDLPKK VQNVLLHGSG DDEIKFSYED GVRSYDTKKP 420
FEGVVTNIER RFRETESEWA REELGKYFSD VPCDACHGHR LKPEALCVKV GGKHIGEVSE 480
LSVKAAGDWF AKVPEVLNKQ QNEIAVRILK EIRDRLSFLL DVGLNYLTLS RSSGTLSGGE 540
SQRIRLASQI GSGLTGVLYV LDEPSIGLHQ RDNARLLDTL KRLRDLGNTV IVVEHDEDAI 600
LLADHVLDIG PGAGVHGGHI IAQGTPAEIM RNPKSLTGKY LTGELSVPVP ERRPPNHRRT 660
LKLVNARGNN LKNVTAEIPL GLFTCVTGVS GGGKSTLLID TFYKAIARKL NNASEPPAPY 720
DRIEGLEHID KIIDIDQSPI GRTPRSNPAT YTGAFTPIRE WFAGLPESKA RGYEPGRFSF 780
NVKGGRCEAC QGDGVIKIEM HFLPDVYVTC DVCKGKRYNR ETLDVLFKGK SIADVLDMTI 840
EEAAEFFKAV PRVRETFKTL QRVGLDYIHV GQQATTLSGG EAQRVKLAKE LSKRATGRTL 900
YILDEPTTGL HFHDVAKLLE VLHELVAQGN TVVVIEHNLE VIKTADWVID LGPEGGDGGG 960
EIVAWGPPED IVKAPRSYTG KFLKPVLEKK GPAKALKRKA DEAAE 1005 
Gene Ontology
 GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:HAMAP.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0009380; C:excinuclease repair complex; IEA:InterPro.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:HAMAP.
 GO:0009381; F:excinuclease ABC activity; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0006289; P:nucleotide-excision repair; IEA:HAMAP.
 GO:0009432; P:SOS response; IEA:HAMAP.
 GO:0006810; P:transport; IEA:HAMAP. 
Interpro
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR013815; ATP_grasp_subdomain_1.
 IPR027417; P-loop_NTPase.
 IPR004602; UvrA. 
Pfam
 PF00005; ABC_tran 
SMART
  
PROSITE
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS