| Tag | Content |
|---|
| CPLM ID | CPLM-022667 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DnaJ homolog subfamily C member 7 |
Protein Synonyms/Alias | Cytoplasmic CAR retention protein; CCRP; MDj11; Tetratricopeptide repeat protein 2; TPR repeat protein 2 |
Gene Name | Dnajc7 |
Gene Synonyms/Alias | Ttc2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 147 | NAVMEYEKIAEVDFE | ubiquitination | [1] | | 155 | IAEVDFEKRDFRKVV | ubiquitination | [1] | | 182 | CHRFKILKAECLAML | ubiquitination | [1] | | 273 | AFKEGNYKLAYELYT | ubiquitination | [1] | | 295 | NNIKTNAKLYCNRGT | ubiquitination | [1] | | 329 | KLDDTYIKAYLRRAQ | ubiquitination | [1] | | 384 | SKRKDYYKILGVDKN | ubiquitination | [1] | | 390 | YKILGVDKNASEDEI | ubiquitination | [1] | | 442 | FTILSDPKKKTRYDS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes (By similarity). Recruits NR1I3 to the cytoplasm. |
Sequence Annotation | REPEAT 28 61 TPR 1.
REPEAT 62 95 TPR 2.
REPEAT 96 129 TPR 3.
REPEAT 142 175 TPR 4.
REPEAT 210 243 TPR 5.
REPEAT 256 289 TPR 6.
REPEAT 294 327 TPR 7.
REPEAT 328 361 TPR 8.
DOMAIN 381 451 J.
MOD_RES 2 2 N-acetylalanine (By similarity). |
Keyword | Acetylation; Chaperone; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 494 AA |
Protein Sequence | MAATAECDVV MAATEPELLE DEDAKREAES FKEQGNAYYA KKDYNEAYNY YTKAIDMCPN 60
NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ 120
RALELDHKNA QAQQEFKNAN AVMEYEKIAE VDFEKRDFRK VVFCMDRALE FAPACHRFKI 180
LKAECLAMLG RYPEAQFVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA 240
PDHEKACVAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR 300
GTVNSKLRQL EDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQFEEAVRD YEKVYQTEKT 360
KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV 420
QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDANNIFK AFFGGPGGFS 480
FEASGPGNFY FQFG 494 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0070389; P:chaperone cofactor-dependent protein refolding; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |