CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040584
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 LIM domain and actin-binding protein 1 
Protein Synonyms/Alias
  
Gene Name
 LIMA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26ENTDASGKIEKYNVPubiquitination[1]
120KYQAAVSKQSSSTNYubiquitination[1, 2]
132TNYTNELKASGGEIKubiquitination[1, 2]
301GFGHRPHKDLWASKNubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 598 AA 
Protein Sequence
MENCLGESRH EVEKSEISEN TDASGKIEKY NVPLNRLKMM FEKGEPTQTK ILRAQSRSAS 60
GRKISENSYS LDDLEIGPGQ LSSSTFDSEK NESRRNLELP RLSETSIKDR MAKYQAAVSK 120
QSSSTNYTNE LKASGGEIKI HKMEQKENVP PGPEVCITHQ EGEKISANEN SLAVRSTPAE 180
DDSRDSQVKS EVQQPVHPKP LSPDSRASSL SESSPPKAMK FQAPARETCV ECQKTVYPME 240
RLLANQQVFH ISCFRCSYCN NKLSLGTYAS LHGRIYCKPH FNQLFKSKGN YDEGFGHRPH 300
KDLWASKNEN EEILERPAQL ANARETPHSP GVEDAPIAKV GVLAASMEAK ASSQQEKEDK 360
PAETKKLRIA WPPPTELGSS GSALEEGIKM SKPKWPPEDE ISKPEVPEDV DLDLKKLRRS 420
SSLKERSRPF TVAASFQSTS VKSPKTVSPP IRKGWSMSEQ SEESVGGRVA ERKQVENAKA 480
SKKNGNVGKT TWQNKESKGE TGKRSKEGHS LEMENENLVE NGADSDEDDN SFLKQQSPQE 540
PKSLNWSSFV DNTFAEEFTT QNQKSQDVEL WEGEVVKELS VEEQIKRNRY YDEDEDEE 598 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS