UniProt Accession

 SRSF7_MOUSE; Q8BL97; Q8BMC6; Q8BUR2; Q8R2N4; Q8R3E9; Q91YS1 

Genbank Protein ID

 AK032861; AK045884; AK082848; BC014857; BC025529; BC027391 

Genbank Nucleotide ID

 BAC28058.1; BAC32521.1; BAC38650.1; AAH14857.1; AAH25529.1; AAH27391.1 

Protein Name

 Serine/arginine-rich splicing factor 7 

Protein Synonyms/Alias

 Splicing factor, arginine/serine-rich 7 

Gene Name

 Srsf7 

Gene Synonyms/Alias

 Sfrs7 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
53	NLGTGAGKGELERAF	acetylation	[1, 2, 3]
53	NLGTGAGKGELERAF	succinylation	[3]
53	NLGTGAGKGELERAF	ubiquitination	[4]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (By similarity). 

Sequence Annotation

 DOMAIN 40 113 RRM.
 REPEAT 182 189 1.
 REPEAT 190 197 2.
 REPEAT 198 205 3.
 REPEAT 206 213 4.
 REPEAT 240 247 5; approximate.
 REPEAT 248 255 6; approximate.
 ZN_FING 133 150 CCHC-type.
 REGION 182 255 6 X 8 AA repeats of R-R-S-R-S-X-S-X.
 MOD_RES 53 53 N6-acetyllysine (By similarity).
 MOD_RES 192 192 Phosphoserine.
 MOD_RES 194 194 Phosphoserine.
 MOD_RES 196 196 Phosphoserine.
 MOD_RES 208 208 Phosphoserine.
 MOD_RES 210 210 Phosphoserine.
 MOD_RES 212 212 Phosphoserine.
 MOD_RES 216 216 Phosphoserine.
 MOD_RES 221 221 Phosphoserine (By similarity).
 MOD_RES 223 223 Phosphoserine (By similarity).
 MOD_RES 225 225 Phosphoserine (By similarity).
 MOD_RES 252 252 Phosphoserine.
 MOD_RES 254 254 Phosphoserine.
 MOD_RES 256 256 Phosphoserine.
 MOD_RES 260 260 Phosphoserine (By similarity).
 MOD_RES 262 262 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 267 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR001878; Znf_CCHC. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM
 SM00343; ZnF_C2HC 

PROSITE

 PS50102; RRM
 PS50158; ZF_CCHC 

PRINTS