UniProt Accession

 APOC1_MOUSE; P34928; Q505B2 

Genbank Protein ID

 Z22661; Z22660; AK011358; BC019398; BC094638 

Genbank Nucleotide ID

 CAA80375.1; CAA80375.1; BAB27566.1; AAH19398.1; AAH94638.1 

Protein Name

 Apolipoprotein C-I 

Protein Synonyms/Alias

 Apo-CIB; ApoC-IB; Apolipoprotein C1; Truncated apolipoprotein C-I; Apo-CIB'; ApoC-IB' 

Gene Name

 Apoc1 

Gene Synonyms/Alias

 Apoc1b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
42	ESIPDKLKEFGNTLE	ubiquitination	[1]
51	FGNTLEDKARAAIEH	ubiquitination	[1]
60	RAAIEHIKQKEILTK	ubiquitination	[1]
78	WFSEAFGKVKEKLKT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Appears to modulate the interaction of APOE with beta- migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. 

Sequence Annotation

  

Keyword

 Complete proteome; Lipid transport; Reference proteome; Secreted; Signal; Transport; VLDL. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 88 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0034364; C:high-density lipoprotein particle; IEA:Compara.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0005504; F:fatty acid binding; IEA:Compara.
 GO:0004859; F:phospholipase inhibitor activity; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IMP:MGI.
 GO:0034382; P:chylomicron remnant clearance; IEA:Compara.
 GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
 GO:0032375; P:negative regulation of cholesterol transport; IEA:Compara.
 GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Compara.
 GO:0051005; P:negative regulation of lipoprotein lipase activity; IEA:Compara.
 GO:0010900; P:negative regulation of phosphatidylcholine catabolic process; IEA:Compara.
 GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Compara.
 GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Compara.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0034369; P:plasma lipoprotein particle remodeling; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI.
 GO:0034447; P:very-low-density lipoprotein particle clearance; IEA:Compara. 

Interpro

 IPR006781; ApoC-I. 

Pfam

 PF04691; ApoC-I 

SMART

  

PROSITE

  

PRINTS