CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031244
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor tyrosine-protein kinase erbB-2 
Protein Synonyms/Alias
 cDNA FLJ59426, highly similar to Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) 
Gene Name
 ERBB2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
448ETELRKVKVLGSGAFubiquitination[1]
460GAFGTVYKGIWIPDGubiquitination[1, 2, 3]
471IPDGENVKIPVAIKVubiquitination[1, 3]
477VKIPVAIKVLRENTSubiquitination[1]
584VKSPNHVKITDFGLAubiquitination[1]
611DGGKVPIKWMALESIubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 979 AA 
Protein Sequence
MELAALCRWG LLLALLPPGA ASTQDNYLST DVGSCTLVCP LHNQEVTAED GTQRCEKCSK 60
PCARVCYGLG MEHLREVRAV TSANIQEFAG CKKIFGSLAF LPESFDGDPA SNTAPLQPEQ 120
LQVFETLEEI TGYLYISAWP DSLPDLSVFQ NLQVIRGRIL HNGAYSLTLQ GLGISWLGLR 180
SLRELGSGLA LIHHNTHLCF VHTVPWDQLF RNPHQALLHT ANRPEDECVG EGLACHQLCA 240
RGHCWGPGPT QCVNCSQFLR GQECVEECRV LQGLPREYVN ARHCLPCHPE CQPQNGSVTC 300
FGPEADQCVA CAHYKDPPFC VARCPSGVKP DLSYMPIWKF PDEEGACQPC PINCTHSCVD 360
LDDKGCPAEQ RASPLTSIIS AVVGILLVVV LGVVFGILIK RRQQKIRKYT MRRLLQETEL 420
VEPLTPSGAM PNQAQMRILK ETELRKVKVL GSGAFGTVYK GIWIPDGENV KIPVAIKVLR 480
ENTSPKANKE ILDEAYVMAG VGSPYVSRLL GICLTSTVQL VTQLMPYGCL LDHVRENRGR 540
LGSQDLLNWC MQIAKGMSYL EDVRLVHRDL AARNVLVKSP NHVKITDFGL ARLLDIDETE 600
YHADGGKVPI KWMALESILR RRFTHQSDVW SYGVTVWELM TFGAKPYDGI PAREIPDLLE 660
KGERLPQPPI CTIDVYMIMV KCWMIDSECR PRFRELVSEF SRMARDPQRF VVIQNEDLGP 720
ASPLDSTFYR SLLEDDDMGD LVDAEEYLVP QQGFFCPDPA PGAGGMVHHR HRSSSTRSGG 780
GDLTLGLEPS EEEAPRSPLA PSEGAGSDVF DGDLGMGAAK GLQSLPTHDP SPLQRYSEDP 840
TVPLPSETDG YVAPLTCSPQ PEYVNQPDVR PQPPSPREGP LPAARPAGAT LERPKTLSPG 900
KNGVVKDVFA FGGAVENPEY LTPQGGAAPQ PHPPPAFSPA FDNLYYWDQD PPERGAPPST 960
FKGTPTAENP EYLGLDVPV 979 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000494; EGF_rcpt_L.
 IPR006212; Furin_repeat.
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF07714; Pkinase_Tyr
 PF01030; Recep_L_domain 
SMART
 SM00261; FU
 SM00219; TyrKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.