| Tag | Content |
|---|
| CPLM ID | CPLM-020074 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 251 |
Protein Synonyms/Alias | |
Gene Name | ZNF251 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 487 | QRVHTGEKPYDCGDC | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be involved in transcriptional regulation. |
Sequence Annotation | DOMAIN 15 86 KRAB.
ZN_FING 209 231 C2H2-type 1.
ZN_FING 237 259 C2H2-type 2.
ZN_FING 265 287 C2H2-type 3.
ZN_FING 293 315 C2H2-type 4.
ZN_FING 321 343 C2H2-type 5.
ZN_FING 349 371 C2H2-type 6.
ZN_FING 377 399 C2H2-type 7.
ZN_FING 405 427 C2H2-type 8.
ZN_FING 433 455 C2H2-type 9.
ZN_FING 461 483 C2H2-type 10.
ZN_FING 489 511 C2H2-type 11.
ZN_FING 566 588 C2H2-type 12; degenerate.
ZN_FING 594 616 C2H2-type 13.
ZN_FING 622 644 C2H2-type 14; degenerate. |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 671 AA |
Protein Sequence | MAATFQLPGH QEMPLTFQDV AVYFSQAEGR QLGPQQRALY RDVMLENYGN VASLGFPVPK 60
PELISQLEQG KELWVLNLLG AEEPDILKSC QKDSEVGTKK ELSILNQKFS EEVKTPEFVS 120
RRLLRDNAQA AEFREAWGRE GKLKERVGNS AGQSLNKPNI HKRVLTEATV GRERSLGERT 180
QECSAFDRNL NLDQNVVRLQ RNKTGERVFK CDICSKTFKY NSDLSRHQRS HTGEKPYECG 240
RCGRAFTHSS NLVLHHHIHT GNKPFKCDEC GKTFGLNSHL RLHRRIHTGE KPFGCGECGK 300
AFSRSSTLIQ HRIIHTGEKP YKCNECGRGF SQSPQLTQHQ RIHTGEKPHE CSHCGKAFSR 360
SSSLIQHERI HTGEKPHKCN QCGKAFSQSS SLFLHHRVHT GEKPYVCNEC GRAFGFNSHL 420
TEHVRIHTGE KPYVCNECGK AFRRSSTLVQ HRRVHTGEKP YQCVECGKAF SQSSQLTLHQ 480
RVHTGEKPYD CGDCGKAFSR RSTLIQHQKV HSGETRKCRK HGPAFVHGSS LTADGQIPTG 540
EKHGRAFNHG ANLILRWTVH TGEKSFGCNE YGKAFSPTSR PTEDQIMHAG EKPYKCQECG 600
NAFSGKSTLI QHQVTHTGQK PCHCSVYGKA FSQSSQLTPP QQTRVGEKPA LNDGSKRYFI 660
HIKKIFQERH F 671 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |