UniProt Accession

 IF3M_MOUSE; Q9CZD5; Q14BP1; Q14BP2 

Genbank Protein ID

 AK012733; AK147090; BC115684; BC115685 

Genbank Nucleotide ID

 BAB28438.1; BAE27670.1; AAI15685.1; AAI15686.1 

Protein Name

 Translation initiation factor IF-3, mitochondrial 

Protein Synonyms/Alias

 IF-3(Mt); IF-3Mt; IF3(mt); IF3mt 

Gene Name

 Mtif3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
246	HLSKKEEKAYRESQE	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Initiation factor; Mitochondrion; Protein biosynthesis; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 276 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IC:BHF-UCL.
 GO:0043024; F:ribosomal small subunit binding; ISS:BHF-UCL.
 GO:0008135; F:translation factor activity, nucleic acid binding; ISS:BHF-UCL.
 GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
 GO:0001732; P:formation of translation initiation complex; ISS:BHF-UCL.
 GO:0006446; P:regulation of translational initiation; ISS:BHF-UCL.
 GO:0032790; P:ribosome disassembly; ISS:BHF-UCL. 

Interpro

 IPR001288; Translation_initiation_fac_3.
 IPR019815; Translation_initiation_fac_3_C.
 IPR019814; Translation_initiation_fac_3_N. 

Pfam

 PF00707; IF3_C
 PF05198; IF3_N 

SMART

  

PROSITE

 PS00938; IF3 

PRINTS