CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanylate cyclase soluble subunit alpha-3 
Protein Synonyms/Alias
 GCS-alpha-3; GCS-alpha-1; Soluble guanylate cyclase large subunit 
Gene Name
 GUCY1A3 
Gene Synonyms/Alias
 GUC1A3; GUCSA3; GUCY1A1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
606NNVTLANKFESCSVPubiquitination[1]
615ESCSVPRKINVSPTTubiquitination[1]
627PTTYRLLKDCPGFVFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 481 608 Guanylate cyclase.  
Keyword
 3D-structure; Alternative splicing; cGMP biosynthesis; Complete proteome; Cytoplasm; GTP-binding; Lyase; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 690 AA 
Protein Sequence
MFCTKLKDLK ITGECPFSLL APGQVPNESS EEAAGSSESC KATVPICQDI PEKNIQESLP 60
QRKTSRSRVY LHTLAESICK LIFPEFERLN VALQRTLAKH KIKESRKSLE REDFEKTIAE 120
QAVAAGVPVE VIKESLGEEV FKICYEEDEN ILGVVGGTLK DFLNSFSTLL KQSSHCQEAG 180
KRGRLEDASI LCLDKEDDFL HVYYFFPKRT TSLILPGIIK AAAHVLYETE VEVSLMPPCF 240
HNDCSEFVNQ PYLLYSVHMK STKPSLSPSK PQSSLVIPTS LFCKTFPFHF MFDKDMTILQ 300
FGNGIRRLMN RRDFQGKPNF EEYFEILTPK INQTFSGIMT MLNMQFVVRV RRWDNSVKKS 360
SRVMDLKGQM IYIVESSAIL FLGSPCVDRL EDFTGRGLYL SDIPIHNALR DVVLIGEQAR 420
AQDGLKKRLG KLKATLEQAH QALEEEKKKT VDLLCSIFPC EVAQQLWQGQ VVQAKKFSNV 480
TMLFSDIVGF TAICSQCSPL QVITMLNALY TRFDQQCGEL DVYKVETIGD AYCVAGGLHK 540
ESDTHAVQIA LMALKMMELS DEVMSPHGEP IKMRIGLHSG SVFAGVVGVK MPRYCLFGNN 600
VTLANKFESC SVPRKINVSP TTYRLLKDCP GFVFTPRSRE ELPPNFPSEI PGICHFLDAY 660
QQGTNSKPCF QKKDVEDGNA NFLGKASGID 690 
Gene Ontology
 GO:0008074; C:guanylate cyclase complex, soluble; TAS:ProtInc.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004383; F:guanylate cyclase activity; TAS:ProtInc.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0008015; P:blood circulation; TAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007263; P:nitric oxide mediated signal transduction; TAS:ProtInc.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Compara.
 GO:0008217; P:regulation of blood pressure; IEA:Compara.
 GO:0060087; P:relaxation of vascular smooth muscle; IEA:Compara.
 GO:0052565; P:response to defense-related host nitric oxide production; IEA:Compara. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR011645; Haem_no_assoc-bd.
 IPR011644; Heme_NO-bd. 
Pfam
 PF00211; Guanylate_cyc
 PF07700; HNOB
 PF07701; HNOBA 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS