UniProt Accession

 PGRC1_RAT; P70580; O70606; Q549C4 

Genbank Protein ID

 U63315; AJ005837; AF163321; BC062073 

Genbank Nucleotide ID

 AAB07125.1; CAA06732.1; AAF17359.1; AAH62073.1 

Protein Name

 Membrane-associated progesterone receptor component 1 

Protein Synonyms/Alias

 25-DX; Acidic 25 kDa protein; Ventral midline antigen; VEMA 

Gene Name

 Pgrmc1 

Gene Synonyms/Alias

 25dx; Lewi; Pgrmc 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
102	GKVFDVTKGRKFYGP	acetylation	[1]
105	FDVTKGRKFYGPEGP	acetylation	[1]
163	WDSQFTFKYHHVGKL	acetylation	[1]
169	FKYHHVGKLLKEGEE	acetylation	[1]
172	HHVGKLLKEGEEPTV	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Receptor for progesterone (By similarity). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity. 

Sequence Annotation

 DOMAIN 72 171 Cytochrome b5 heme-binding.
 MOD_RES 54 54 Phosphoserine (By similarity).
 MOD_RES 180 180 Phosphotyrosine (By similarity).
 MOD_RES 181 181 Phosphoserine.  

Keyword

 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Lipid-binding; Membrane; Microsome; Phosphoprotein; Receptor; Reference proteome; Steroid-binding; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 195 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
 GO:0007411; P:axon guidance; IEP:RGD. 

Interpro

 IPR001199; Cyt_B5-like_heme/steroid-bd. 

Pfam

 PF00173; Cyt-b5 

SMART

  

PROSITE

 PS00191; CYTOCHROME_B5_1
 PS50255; CYTOCHROME_B5_2 

PRINTS