CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024030
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-1 complex subunit mu-2 
Protein Synonyms/Alias
 AP-mu chain family member mu1B; Adaptor protein complex AP-1 mu-2 subunit; Adaptor-related protein complex 1 mu-2 subunit; Clathrin assembly protein complex 1 medium chain 2; Golgi adaptor HA1/AP1 adaptin mu-2 subunit; Mu-adaptin 2; Mu1B-adaptin 
Gene Name
 AP1M2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14FILDVKGKPLISRNYubiquitination[1]
22PLISRNYKGDVAMSKubiquitination[1]
29KGDVAMSKIEHFMPLubiquitination[1]
141YITQQSNKLETGKSRubiquitination[1]
146SNKLETGKSRVPPTVubiquitination[1]
201IVGTIKLKVFLSGMPubiquitination[1]
229LTGRSKNKSVELEDVubiquitination[1]
274YRLSTQVKPLIWIESubiquitination[1]
296SRVEIMVKAKGQFKKubiquitination[1]
298VEIMVKAKGQFKKQSubiquitination[1]
303KAKGQFKKQSVANGVubiquitination[1]
326DADSPRFKTSVGSAKubiquitination[1]
333KTSVGSAKYVPERNVubiquitination[1]
367FGLPSVEKEEVEGRPubiquitination[1]
379GRPPIGVKFEIPYFTubiquitination[1]
396GIQVRYMKIIEKSGYubiquitination[1]
400RYMKIIEKSGYQALPubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. 
Sequence Annotation
 DOMAIN 168 421 MHD.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 423 AA 
Protein Sequence
MSASAVFILD VKGKPLISRN YKGDVAMSKI EHFMPLLVQR EEEGALAPLL SHGQVHFLWI 60
KHSNLYLVAT TSKNANASLV YSFLYKTIEV FCEYFKELEE ESIRDNFVIV YELLDELMDF 120
GFPQTTDSKI LQEYITQQSN KLETGKSRVP PTVTNAVSWR SEGIKYKKNE VFIDVIESVN 180
LLVNANGSVL LSEIVGTIKL KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ 240
CVRLSRFDND RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ 300
FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPERNV VIWSIKSFPG GKEYLMRAHF 360
GLPSVEKEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK SGYQALPWVR YITQSGDYQL 420
RTS 423 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005765; C:lysosomal membrane; TAS:Reactome.
 GO:0032588; C:trans-Golgi network membrane; TAS:Reactome.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0006605; P:protein targeting; TAS:ProtInc.
 GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
 GO:0006903; P:vesicle targeting; TAS:ProtInc.
 GO:0016032; P:viral reproduction; TAS:Reactome. 
Interpro
 IPR022775; AP_mu_sigma_su.
 IPR001392; Clathrin_mu.
 IPR008968; Clathrin_mu_C.
 IPR018240; Clathrin_mu_CS.
 IPR011012; Longin-like_dom. 
Pfam
 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 
SMART
  
PROSITE
 PS00990; CLAT_ADAPTOR_M_1
 PS00991; CLAT_ADAPTOR_M_2
 PS51072; MHD 
PRINTS
 PR00314; CLATHRINADPT.