| Tag | Content |
|---|
| CPLM ID | CPLM-001388 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protocadherin alpha-4 |
Protein Synonyms/Alias | PCDH-alpha-4 |
Gene Name | Pcdha4 |
Gene Synonyms/Alias | Cnr1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 897 | TLTNAAGKRDGKAPA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity). |
Sequence Annotation | DOMAIN 30 133 Cadherin 1.
DOMAIN 134 242 Cadherin 2.
DOMAIN 243 350 Cadherin 3.
DOMAIN 351 455 Cadherin 4.
DOMAIN 456 565 Cadherin 5.
DOMAIN 573 681 Cadherin 6.
REPEAT 734 737 PXXP 1.
REPEAT 774 777 PXXP 2.
REPEAT 796 799 PXXP 3.
REPEAT 829 832 PXXP 4.
REPEAT 870 873 PXXP 5.
REPEAT 888 891 PXXP 6.
REGION 734 891 6 X 4 AA repeats of P-X-X-P.
CARBOHYD 257 257 N-linked (GlcNAc...) (Potential).
CARBOHYD 265 265 N-linked (GlcNAc...) (Potential).
CARBOHYD 548 548 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Alternative splicing; Calcium; Cell adhesion; Cell membrane; Complete proteome; Glycoprotein; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 947 AA |
Protein Sequence | MEFSWGSGQE SQRLLLSFLL LAIWEAGNSQ IHYSIPEEAK HGTFVGRIAQ DLGLELTELV 60
PRLFRVASKD RGDLLEVNLQ NGILFVNSRI DREELCGRSA ECSIHLEVIV DRPLQVFHVE 120
VEVRDINDNP PRFPTTQKNL FIAESRPLDT WFPLEGASDA DIGINAVLTY RLSPNDYFSL 180
EKPSNDERVK GLGLVLRKSL DREETPEIIL VLTVTDGGKP ELTGSVQLLI TVLDANDNAP 240
VFDRSLYTVK LPENVPNGTL VVKVNASDLD EGVNGDIMYS FSTDISPNVK YKFHIDPVSG 300
EIIVKGYIDF EECKSYEILI EGIDKGQLPL SGHCKVIVQV EDINDNVPEL EFKSLSLPIR 360
ENSPVGTVIA LISVSDRDTG VNGQVTCSLT SHVPFKLVST FKNYYSLVLD SALDRETTAD 420
YKVVVTARDG GSPSLWATAS VSVEVADVND NAPVFAQPEY TVFVKENNPP GAHIFTVSAM 480
DADAQENALV SYSLVERRVG ERLLSSYVSV HAESGKVFAL QPLDHEELEL LRFQVSARDA 540
GVPALGSNVT LQVFVLDEND NAPTLLEPEA GVSGGIVSRL VSRSVGAGHV VAKVRAVDAD 600
SGYNAWLSYE LQSSEGNSRS LFRVGLYTGE ISTTRILDEA DSPRQRLLVL VKDHGDPAMI 660
VTATVLVSLV ENGPVPKAPS RVSTSVTHSE ASLVDVNVYL IIAICAVSSL LVLTLLLYTA 720
LRCSTVPSES VCGPPKPVMV CSSAVGSWSY SQQRRQRVCS GEYPPKTDLM AFSPSLSDSR 780
DREDQLQSAE DSSGKQAPPN TDWRFSQAQR PGTSGSQNGD ETGTWPNNQF DTEMLQAMIL 840
ASASEAADGS STLGGGAGTM GLSARYGPQF TLQHVPDYRQ NVYIPGSNAT LTNAAGKRDG 900
KAPAGGNGNK KKSGKKEKK 919 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005509; F:calcium ion binding; IEA:InterPro. GO:0007156; P:homophilic cell adhesion; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |