UniProt Accession

 H13_MOUSE; P43277; Q8C6M4 

Genbank Protein ID

 Z38128; U62923; AY158906; AK054269 

Genbank Nucleotide ID

 CAA86288.1; AAB05799.1; AAO06217.1; BAC35711.1 

Protein Name

 Histone H1.3 

Protein Synonyms/Alias

 H1 VAR.4; H1d 

Gene Name

 Hist1h1d 

Gene Synonyms/Alias

 H1f3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
17	AAPAPVEKTPVKKKA	acetylation	[1, 2]
33	KTGAAAGKRKASGPP	acetylation	[3]
35	GAAAGKRKASGPPVS	ubiquitination	[4]
47	PVSELITKAVAASKE	acetylation	[5]
47	PVSELITKAVAASKE	ubiquitination	[4]
53	TKAVAASKERSGVSL	acetylation	[5]
86	SRIKLGLKSLVSKGT	acetylation	[5]
91	GLKSLVSKGTLVQTK	acetylation	[5, 6]
128	AKKAGAAKAKKPAGA	acetylation	[6]
137	KKPAGAAKKPKKATG	acetylation	[6]
138	KPAGAAKKPKKATGA	acetylation	[6]
161	KTPKKAKKPAAAAGA	acetylation	[6]
169	PAAAAGAKKVSKSPK	acetylation	[5, 6]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [5] Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue.
 Wisniewski JR, Zougman A, Krüger S, Mann M.
 Mol Cell Proteomics. 2007 Jan;6(1):72-87. [PMID: 17043054]
 [6] Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain.
 Tweedie-Cullen RY, Reck JM, Mansuy IM.
 J Proteome Res. 2009 Nov;8(11):4966-82. [PMID: 19737024] 

Functional Description

 Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). 

Sequence Annotation

 DOMAIN 37 110 H15.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine (By similarity).
 MOD_RES 18 18 Phosphothreonine.
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 105 105 Phosphoserine; by PKC (By similarity).  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 221 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IEA:Compara.
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0016584; P:nucleosome positioning; IMP:MGI. 

Interpro

 IPR005818; Histone_H1/H5.
 IPR005819; Histone_H5.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00538; Linker_histone 

SMART

 SM00526; H15 

PROSITE

 PS51504; H15 

PRINTS

 PR00624; HISTONEH5.