CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012952
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrator complex subunit 11 
Protein Synonyms/Alias
 Int11; Cleavage and polyadenylation-specific factor 3-like protein; CPSF3-like protein 
Gene Name
 Cpsf3l 
Gene Synonyms/Alias
 Ints11 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
115RKIAVDKKGEANFFTubiquitination[1]
234ETVERGGKVLIPVFAubiquitination[1]
426KMEFLRQKIEQEFRVubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage (By similarity). 
Sequence Annotation
 MOTIF 68 73 HXHXDH motif.  
Keyword
 Complete proteome; Cytoplasm; Hydrolase; Nucleus; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 600 AA 
Protein Sequence
MPEIRVTPLG AGQDVGRSCI LVSISGKNVM LDCGMHMGYN DDRRFPDFSY ITQSGRLTDF 60
LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF 120
FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN 180
MTPDRHLGAA WIDKCRPNLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF 240
ALGRAQELCI LLETFWERMN LKVPIYFSTG LTEKANHYYK LFITWTNQKI RKTFVQRNMF 300
EFKHIKAFDR TFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG 360
HKILSGQRKL EMEGRQMLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPESV LLVHGEAKKM 420
EFLRQKIEQE FRVSCYMPAN GETVTLPTSP SIPVGISLGL LKREMVQGLL PEAKKPRLLH 480
GTLIMKDNNF RLVSSEQALK ELGLAEHQLR FTCRVHLQDT RKEQETALRV YSHLKSTLKD 540
HCVQHLPDGS VTVESILIQA AAHSEDPGTK VLLVSWTYQD EELGSFLTAL LKNGLPQAPS 600 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 
Interpro
 IPR001279; Beta-lactamas-like.
 IPR022712; Beta_Casp.
 IPR011108; RMMBL. 
Pfam
 PF10996; Beta-Casp
 PF00753; Lactamase_B
 PF07521; RMMBL 
SMART
 SM01027; Beta-Casp
 SM00849; Lactamase_B 
PROSITE
  
PRINTS